Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea

Zollinger-Ellison syndrome (ZES) is caused by hypersecretion of gastrin from duodenal or pancreatic gastrinomas. We report a case of a 57-year-old female who presented with chronic diarrhea. CT abdomen showed multiple liver masses. Liver biopsy suggested metastatic well-differentiated neuroendocrine...

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Autores principales: Aamar, Ali, Madhani, Kamraan, Virk, Hafeezulhassan, Butt, Zeeshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191898/
https://www.ncbi.nlm.nih.gov/pubmed/28058079
http://dx.doi.org/10.14740/gr734w
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author Aamar, Ali
Madhani, Kamraan
Virk, Hafeezulhassan
Butt, Zeeshan
author_facet Aamar, Ali
Madhani, Kamraan
Virk, Hafeezulhassan
Butt, Zeeshan
author_sort Aamar, Ali
collection PubMed
description Zollinger-Ellison syndrome (ZES) is caused by hypersecretion of gastrin from duodenal or pancreatic gastrinomas. We report a case of a 57-year-old female who presented with chronic diarrhea. CT abdomen showed multiple liver masses. Liver biopsy suggested metastatic well-differentiated neuroendocrine tumor. Serum gastrin level was markedly elevated. MRI abdomen, somatostatin receptor scintigraphy and endoscopic ultrasound failed to reveal primary site of the tumor. Upper gastrointestinal endoscopy showed hyperplastic gastric folds and multiple duodenal ulcers consistent with ZES. Patient was started on high-dose omeprazole and octreotide resulting in improvement in diarrhea.
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spelling pubmed-51918982017-01-05 Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea Aamar, Ali Madhani, Kamraan Virk, Hafeezulhassan Butt, Zeeshan Gastroenterology Res Case Report Zollinger-Ellison syndrome (ZES) is caused by hypersecretion of gastrin from duodenal or pancreatic gastrinomas. We report a case of a 57-year-old female who presented with chronic diarrhea. CT abdomen showed multiple liver masses. Liver biopsy suggested metastatic well-differentiated neuroendocrine tumor. Serum gastrin level was markedly elevated. MRI abdomen, somatostatin receptor scintigraphy and endoscopic ultrasound failed to reveal primary site of the tumor. Upper gastrointestinal endoscopy showed hyperplastic gastric folds and multiple duodenal ulcers consistent with ZES. Patient was started on high-dose omeprazole and octreotide resulting in improvement in diarrhea. Elmer Press 2016-12 2016-12-23 /pmc/articles/PMC5191898/ /pubmed/28058079 http://dx.doi.org/10.14740/gr734w Text en Copyright 2016, Aamar et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Aamar, Ali
Madhani, Kamraan
Virk, Hafeezulhassan
Butt, Zeeshan
Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea
title Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea
title_full Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea
title_fullStr Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea
title_full_unstemmed Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea
title_short Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea
title_sort zollinger-ellison syndrome: a rare case of chronic diarrhea
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191898/
https://www.ncbi.nlm.nih.gov/pubmed/28058079
http://dx.doi.org/10.14740/gr734w
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