Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive...

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Autores principales: Muthusamy, Nagendran, Zhang, Xuying, Johnson, Caroline A., Yadav, Prem N., Ghashghaei, H. Troy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191939/
https://www.ncbi.nlm.nih.gov/pubmed/27918532
http://dx.doi.org/10.1038/nn.4452
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author Muthusamy, Nagendran
Zhang, Xuying
Johnson, Caroline A.
Yadav, Prem N.
Ghashghaei, H. Troy
author_facet Muthusamy, Nagendran
Zhang, Xuying
Johnson, Caroline A.
Yadav, Prem N.
Ghashghaei, H. Troy
author_sort Muthusamy, Nagendran
collection PubMed
description Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult born neurons, unveiling that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.
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spelling pubmed-51919392017-06-05 Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning Muthusamy, Nagendran Zhang, Xuying Johnson, Caroline A. Yadav, Prem N. Ghashghaei, H. Troy Nat Neurosci Article Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult born neurons, unveiling that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning. 2016-12-05 2017-01 /pmc/articles/PMC5191939/ /pubmed/27918532 http://dx.doi.org/10.1038/nn.4452 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Muthusamy, Nagendran
Zhang, Xuying
Johnson, Caroline A.
Yadav, Prem N.
Ghashghaei, H. Troy
Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
title Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
title_full Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
title_fullStr Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
title_full_unstemmed Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
title_short Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
title_sort developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191939/
https://www.ncbi.nlm.nih.gov/pubmed/27918532
http://dx.doi.org/10.1038/nn.4452
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