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O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway

Tumors utilize aerobic glycolysis to support growth and invasion. However, the molecular mechanisms that link metabolism with invasion are not well understood. The nutrient sensor O-linked-β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) modifies intracellular proteins with N-acetylglucosamine. Ca...

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Detalles Bibliográficos
Autores principales:	Ferrer, Christina M., Lu, Tong Y., Bacigalupa, Zachary A., Katsetos, Christos D., Sinclair, David A., Reginato, Mauricio J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192006/ https://www.ncbi.nlm.nih.gov/pubmed/27345396 http://dx.doi.org/10.1038/onc.2016.228

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