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Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of (14)C-Omadacycline in Rats

The absorption, distribution, metabolism, and excretion (ADME) of omadacycline, a first-in-class aminomethylcycline antibiotic with a broad spectrum of activity against Gram-positive, Gram-negative, anaerobic, and atypical bacteria, were evaluated in rats. Tissue distribution was investigated by qua...

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Detalles Bibliográficos
Autores principales:	Lin, Wen, Flarakos, Jimmy, Du, Yancy, Hu, Wenyu, He, Handan, Mangold, James, Tanaka, S. Ken, Villano, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192155/ https://www.ncbi.nlm.nih.gov/pubmed/27821446 http://dx.doi.org/10.1128/AAC.01784-16

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