Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus

Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensit...

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Autores principales: Aqrabawi, Afif J., Browne, Caleb J., Dargaei, Zahra, Garand, Danielle, Khademullah, C. Sahara, Woodin, Melanie A., Kim, Jun Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192165/
https://www.ncbi.nlm.nih.gov/pubmed/28004701
http://dx.doi.org/10.1038/ncomms13721
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author Aqrabawi, Afif J.
Browne, Caleb J.
Dargaei, Zahra
Garand, Danielle
Khademullah, C. Sahara
Woodin, Melanie A.
Kim, Jun Chul
author_facet Aqrabawi, Afif J.
Browne, Caleb J.
Dargaei, Zahra
Garand, Danielle
Khademullah, C. Sahara
Woodin, Melanie A.
Kim, Jun Chul
author_sort Aqrabawi, Afif J.
collection PubMed
description Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.
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spelling pubmed-51921652017-01-03 Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus Aqrabawi, Afif J. Browne, Caleb J. Dargaei, Zahra Garand, Danielle Khademullah, C. Sahara Woodin, Melanie A. Kim, Jun Chul Nat Commun Article Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours. Nature Publishing Group 2016-12-22 /pmc/articles/PMC5192165/ /pubmed/28004701 http://dx.doi.org/10.1038/ncomms13721 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Aqrabawi, Afif J.
Browne, Caleb J.
Dargaei, Zahra
Garand, Danielle
Khademullah, C. Sahara
Woodin, Melanie A.
Kim, Jun Chul
Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
title Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
title_full Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
title_fullStr Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
title_full_unstemmed Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
title_short Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
title_sort top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192165/
https://www.ncbi.nlm.nih.gov/pubmed/28004701
http://dx.doi.org/10.1038/ncomms13721
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