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Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial

AIM: To analyze the effects of premedication with Pronase for endoscopic ultrasound (EUS) examination of the stomach. METHODS: This was a prospective, randomized and controlled clinical study. All patients were randomly assigned to either the Pronase group or placebo group. The pretreatment solution...

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Autores principales: Wang, Guo-Xin, Liu, Xiang, Wang, Sheng, Ge, Nan, Guo, Jin-Tao, Sun, Si-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192279/
https://www.ncbi.nlm.nih.gov/pubmed/28082820
http://dx.doi.org/10.3748/wjg.v22.i48.10673
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author Wang, Guo-Xin
Liu, Xiang
Wang, Sheng
Ge, Nan
Guo, Jin-Tao
Sun, Si-Yu
author_facet Wang, Guo-Xin
Liu, Xiang
Wang, Sheng
Ge, Nan
Guo, Jin-Tao
Sun, Si-Yu
author_sort Wang, Guo-Xin
collection PubMed
description AIM: To analyze the effects of premedication with Pronase for endoscopic ultrasound (EUS) examination of the stomach. METHODS: This was a prospective, randomized and controlled clinical study. All patients were randomly assigned to either the Pronase group or placebo group. The pretreatment solution was a mixed solution of 20000 U of Pronase and 60 mL sodium bicarbonate solution in the Pronase group, while an equal amount of sodium bicarbonate solution was administered to the placebo group. All operators, image evaluators and experimental recorders in EUS did not participate in the preparation and allocation of pretreatment solution. Two blinded investigators assessed the obscurity scores for the EUS images according to the size of artifacts (including ultrasound images of the gastric cavity and the gastric wall). Differences in imaging quality, the duration of examination and the usage of physiological saline during the examination process between the Pronase group and the control group were compared. RESULTS: No differences existed in patient demographics between the two groups. For the gastric cavity, the Pronase group had significantly lower mean obscurity scores than the placebo group (1.0476 ± 0.77 vs 1.6129 ± 0.96, respectively, P = 0.000). The mean obscurity scores for the gastric mucosal surface were significantly lower in the Pronase group than the placebo group (1.2063 ± 0.90 vs 1.7581 ± 0.84, respectively, P = 0.001). The average EUS procedure duration for the Pronase group was 11.60 ± 3.32 min, which was significantly shorter than that of the placebo group (13.13 ± 3.81 min, P = 0.007). Less saline was used in the Pronase group than the placebo group, and the difference was significant (417.94 ± 121.38 mL vs 467.42 ± 104.52 mL, respectively, P = 0.016). CONCLUSION: The group that had Pronase premedication prior to the EUS examination had clearer images than the placebo group. With Pronase premedication, the examination time was shorter, and the amount of saline used during the EUS examination was less.
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spelling pubmed-51922792017-01-12 Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial Wang, Guo-Xin Liu, Xiang Wang, Sheng Ge, Nan Guo, Jin-Tao Sun, Si-Yu World J Gastroenterol Randomized Controlled Trial AIM: To analyze the effects of premedication with Pronase for endoscopic ultrasound (EUS) examination of the stomach. METHODS: This was a prospective, randomized and controlled clinical study. All patients were randomly assigned to either the Pronase group or placebo group. The pretreatment solution was a mixed solution of 20000 U of Pronase and 60 mL sodium bicarbonate solution in the Pronase group, while an equal amount of sodium bicarbonate solution was administered to the placebo group. All operators, image evaluators and experimental recorders in EUS did not participate in the preparation and allocation of pretreatment solution. Two blinded investigators assessed the obscurity scores for the EUS images according to the size of artifacts (including ultrasound images of the gastric cavity and the gastric wall). Differences in imaging quality, the duration of examination and the usage of physiological saline during the examination process between the Pronase group and the control group were compared. RESULTS: No differences existed in patient demographics between the two groups. For the gastric cavity, the Pronase group had significantly lower mean obscurity scores than the placebo group (1.0476 ± 0.77 vs 1.6129 ± 0.96, respectively, P = 0.000). The mean obscurity scores for the gastric mucosal surface were significantly lower in the Pronase group than the placebo group (1.2063 ± 0.90 vs 1.7581 ± 0.84, respectively, P = 0.001). The average EUS procedure duration for the Pronase group was 11.60 ± 3.32 min, which was significantly shorter than that of the placebo group (13.13 ± 3.81 min, P = 0.007). Less saline was used in the Pronase group than the placebo group, and the difference was significant (417.94 ± 121.38 mL vs 467.42 ± 104.52 mL, respectively, P = 0.016). CONCLUSION: The group that had Pronase premedication prior to the EUS examination had clearer images than the placebo group. With Pronase premedication, the examination time was shorter, and the amount of saline used during the EUS examination was less. Baishideng Publishing Group Inc 2016-12-28 2016-12-28 /pmc/articles/PMC5192279/ /pubmed/28082820 http://dx.doi.org/10.3748/wjg.v22.i48.10673 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Randomized Controlled Trial
Wang, Guo-Xin
Liu, Xiang
Wang, Sheng
Ge, Nan
Guo, Jin-Tao
Sun, Si-Yu
Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial
title Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial
title_full Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial
title_fullStr Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial
title_full_unstemmed Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial
title_short Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial
title_sort effects of premedication with pronase for endoscopic ultrasound of the stomach: a randomized controlled trial
topic Randomized Controlled Trial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192279/
https://www.ncbi.nlm.nih.gov/pubmed/28082820
http://dx.doi.org/10.3748/wjg.v22.i48.10673
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