Cargando…
The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relation...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192295/ https://www.ncbi.nlm.nih.gov/pubmed/28070138 http://dx.doi.org/10.1155/2016/6869415 |
_version_ | 1782487744349470720 |
---|---|
author | Qiu, Guanglin Li, Xuqi Wei, Chao Che, Xiangming He, Shicai Lu, Jing Wang, Shufeng Pang, Ke Fan, Lin |
author_facet | Qiu, Guanglin Li, Xuqi Wei, Chao Che, Xiangming He, Shicai Lu, Jing Wang, Shufeng Pang, Ke Fan, Lin |
author_sort | Qiu, Guanglin |
collection | PubMed |
description | Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relationship in GC patients. Methods. Transmission electron microscopy (TEM) was performed to examine the autophagy in GC patients. Immunohistochemistry was used to examine the expression of SIRT1, Beclin-1 in GC, and adjacent nonneoplastic mucosa. Results. In 7 out of 8 GC patients' samples examined by TEM, more autophagic vesicles were observed in GC tissues compared to adjacent nonneoplastic mucosa tissue. A positive correlation between SIRT1 and Beclin-1 expression was observed. Furthermore, Beclin-1 or SIRT1 expression alone or their combined expression were significantly correlated with advanced clinicopathological parameters. High Beclin-1 and SIRT1 expression alone and their combined high expression predicted shorter overall survival and relapse-free survival. Both high Beclin-1 and SIRT1 expressions were independent prognostic factors for poor survival of GC. Conclusions. Based on our results we can conclude that SIRT1 and Beclin-1 expression alone or in combination can be used as prognostic indicator and may represent new therapeutic targets in GC. |
format | Online Article Text |
id | pubmed-5192295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51922952017-01-09 The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer Qiu, Guanglin Li, Xuqi Wei, Chao Che, Xiangming He, Shicai Lu, Jing Wang, Shufeng Pang, Ke Fan, Lin Dis Markers Research Article Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relationship in GC patients. Methods. Transmission electron microscopy (TEM) was performed to examine the autophagy in GC patients. Immunohistochemistry was used to examine the expression of SIRT1, Beclin-1 in GC, and adjacent nonneoplastic mucosa. Results. In 7 out of 8 GC patients' samples examined by TEM, more autophagic vesicles were observed in GC tissues compared to adjacent nonneoplastic mucosa tissue. A positive correlation between SIRT1 and Beclin-1 expression was observed. Furthermore, Beclin-1 or SIRT1 expression alone or their combined expression were significantly correlated with advanced clinicopathological parameters. High Beclin-1 and SIRT1 expression alone and their combined high expression predicted shorter overall survival and relapse-free survival. Both high Beclin-1 and SIRT1 expressions were independent prognostic factors for poor survival of GC. Conclusions. Based on our results we can conclude that SIRT1 and Beclin-1 expression alone or in combination can be used as prognostic indicator and may represent new therapeutic targets in GC. Hindawi Publishing Corporation 2016 2016-12-14 /pmc/articles/PMC5192295/ /pubmed/28070138 http://dx.doi.org/10.1155/2016/6869415 Text en Copyright © 2016 Guanglin Qiu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Qiu, Guanglin Li, Xuqi Wei, Chao Che, Xiangming He, Shicai Lu, Jing Wang, Shufeng Pang, Ke Fan, Lin The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer |
title | The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer |
title_full | The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer |
title_fullStr | The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer |
title_full_unstemmed | The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer |
title_short | The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer |
title_sort | prognostic role of sirt1-autophagy axis in gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192295/ https://www.ncbi.nlm.nih.gov/pubmed/28070138 http://dx.doi.org/10.1155/2016/6869415 |
work_keys_str_mv | AT qiuguanglin theprognosticroleofsirt1autophagyaxisingastriccancer AT lixuqi theprognosticroleofsirt1autophagyaxisingastriccancer AT weichao theprognosticroleofsirt1autophagyaxisingastriccancer AT chexiangming theprognosticroleofsirt1autophagyaxisingastriccancer AT heshicai theprognosticroleofsirt1autophagyaxisingastriccancer AT lujing theprognosticroleofsirt1autophagyaxisingastriccancer AT wangshufeng theprognosticroleofsirt1autophagyaxisingastriccancer AT pangke theprognosticroleofsirt1autophagyaxisingastriccancer AT fanlin theprognosticroleofsirt1autophagyaxisingastriccancer AT qiuguanglin prognosticroleofsirt1autophagyaxisingastriccancer AT lixuqi prognosticroleofsirt1autophagyaxisingastriccancer AT weichao prognosticroleofsirt1autophagyaxisingastriccancer AT chexiangming prognosticroleofsirt1autophagyaxisingastriccancer AT heshicai prognosticroleofsirt1autophagyaxisingastriccancer AT lujing prognosticroleofsirt1autophagyaxisingastriccancer AT wangshufeng prognosticroleofsirt1autophagyaxisingastriccancer AT pangke prognosticroleofsirt1autophagyaxisingastriccancer AT fanlin prognosticroleofsirt1autophagyaxisingastriccancer |