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The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer

Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relation...

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Autores principales: Qiu, Guanglin, Li, Xuqi, Wei, Chao, Che, Xiangming, He, Shicai, Lu, Jing, Wang, Shufeng, Pang, Ke, Fan, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192295/
https://www.ncbi.nlm.nih.gov/pubmed/28070138
http://dx.doi.org/10.1155/2016/6869415
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author Qiu, Guanglin
Li, Xuqi
Wei, Chao
Che, Xiangming
He, Shicai
Lu, Jing
Wang, Shufeng
Pang, Ke
Fan, Lin
author_facet Qiu, Guanglin
Li, Xuqi
Wei, Chao
Che, Xiangming
He, Shicai
Lu, Jing
Wang, Shufeng
Pang, Ke
Fan, Lin
author_sort Qiu, Guanglin
collection PubMed
description Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relationship in GC patients. Methods. Transmission electron microscopy (TEM) was performed to examine the autophagy in GC patients. Immunohistochemistry was used to examine the expression of SIRT1, Beclin-1 in GC, and adjacent nonneoplastic mucosa. Results. In 7 out of 8 GC patients' samples examined by TEM, more autophagic vesicles were observed in GC tissues compared to adjacent nonneoplastic mucosa tissue. A positive correlation between SIRT1 and Beclin-1 expression was observed. Furthermore, Beclin-1 or SIRT1 expression alone or their combined expression were significantly correlated with advanced clinicopathological parameters. High Beclin-1 and SIRT1 expression alone and their combined high expression predicted shorter overall survival and relapse-free survival. Both high Beclin-1 and SIRT1 expressions were independent prognostic factors for poor survival of GC. Conclusions. Based on our results we can conclude that SIRT1 and Beclin-1 expression alone or in combination can be used as prognostic indicator and may represent new therapeutic targets in GC.
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spelling pubmed-51922952017-01-09 The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer Qiu, Guanglin Li, Xuqi Wei, Chao Che, Xiangming He, Shicai Lu, Jing Wang, Shufeng Pang, Ke Fan, Lin Dis Markers Research Article Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relationship in GC patients. Methods. Transmission electron microscopy (TEM) was performed to examine the autophagy in GC patients. Immunohistochemistry was used to examine the expression of SIRT1, Beclin-1 in GC, and adjacent nonneoplastic mucosa. Results. In 7 out of 8 GC patients' samples examined by TEM, more autophagic vesicles were observed in GC tissues compared to adjacent nonneoplastic mucosa tissue. A positive correlation between SIRT1 and Beclin-1 expression was observed. Furthermore, Beclin-1 or SIRT1 expression alone or their combined expression were significantly correlated with advanced clinicopathological parameters. High Beclin-1 and SIRT1 expression alone and their combined high expression predicted shorter overall survival and relapse-free survival. Both high Beclin-1 and SIRT1 expressions were independent prognostic factors for poor survival of GC. Conclusions. Based on our results we can conclude that SIRT1 and Beclin-1 expression alone or in combination can be used as prognostic indicator and may represent new therapeutic targets in GC. Hindawi Publishing Corporation 2016 2016-12-14 /pmc/articles/PMC5192295/ /pubmed/28070138 http://dx.doi.org/10.1155/2016/6869415 Text en Copyright © 2016 Guanglin Qiu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qiu, Guanglin
Li, Xuqi
Wei, Chao
Che, Xiangming
He, Shicai
Lu, Jing
Wang, Shufeng
Pang, Ke
Fan, Lin
The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
title The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
title_full The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
title_fullStr The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
title_full_unstemmed The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
title_short The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
title_sort prognostic role of sirt1-autophagy axis in gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192295/
https://www.ncbi.nlm.nih.gov/pubmed/28070138
http://dx.doi.org/10.1155/2016/6869415
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