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Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading

Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in par...

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Autores principales: Apinun, Jirun, Sengprasert, Panjana, Yuktanandana, Pongsak, Ngarmukos, Srihatach, Tanavalee, Aree, Reantragoon, Rangsima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192329/
https://www.ncbi.nlm.nih.gov/pubmed/28070192
http://dx.doi.org/10.1155/2016/9525724
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author Apinun, Jirun
Sengprasert, Panjana
Yuktanandana, Pongsak
Ngarmukos, Srihatach
Tanavalee, Aree
Reantragoon, Rangsima
author_facet Apinun, Jirun
Sengprasert, Panjana
Yuktanandana, Pongsak
Ngarmukos, Srihatach
Tanavalee, Aree
Reantragoon, Rangsima
author_sort Apinun, Jirun
collection PubMed
description Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading. Our results show that CD8+ T cells are increased in osteoarthritic patients with higher radiographic grading. When peripheral blood CD8+ T cells were examined, we show that CD8+ T cells possess a significantly higher level of activation than its CD4+ T cell counterpart (P < 0.0001). Our results suggest a role for CD8+ T cells and recruitment of these activated circulating peripheral blood CD8+ T cells to the knee triggering local inflammation within the knee joint.
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spelling pubmed-51923292017-01-09 Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading Apinun, Jirun Sengprasert, Panjana Yuktanandana, Pongsak Ngarmukos, Srihatach Tanavalee, Aree Reantragoon, Rangsima Int J Rheumatol Research Article Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading. Our results show that CD8+ T cells are increased in osteoarthritic patients with higher radiographic grading. When peripheral blood CD8+ T cells were examined, we show that CD8+ T cells possess a significantly higher level of activation than its CD4+ T cell counterpart (P < 0.0001). Our results suggest a role for CD8+ T cells and recruitment of these activated circulating peripheral blood CD8+ T cells to the knee triggering local inflammation within the knee joint. Hindawi Publishing Corporation 2016 2016-12-14 /pmc/articles/PMC5192329/ /pubmed/28070192 http://dx.doi.org/10.1155/2016/9525724 Text en Copyright © 2016 Jirun Apinun et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Apinun, Jirun
Sengprasert, Panjana
Yuktanandana, Pongsak
Ngarmukos, Srihatach
Tanavalee, Aree
Reantragoon, Rangsima
Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading
title Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading
title_full Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading
title_fullStr Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading
title_full_unstemmed Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading
title_short Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading
title_sort immune mediators in osteoarthritis: infrapatellar fat pad-infiltrating cd8+ t cells are increased in osteoarthritic patients with higher clinical radiographic grading
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192329/
https://www.ncbi.nlm.nih.gov/pubmed/28070192
http://dx.doi.org/10.1155/2016/9525724
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