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Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System
Background. Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD). Both of them usually activate a complex range of pathogenic pathways leading to organ damage. Here we hypothesized that dyslipidemia and diabetes could affect...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192341/ https://www.ncbi.nlm.nih.gov/pubmed/28070143 http://dx.doi.org/10.1155/2016/6529728 |
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author | Toffoli, Barbara Fabris, Bruno Bartelloni, Giacomo Bossi, Fleur Bernardi, Stella |
author_facet | Toffoli, Barbara Fabris, Bruno Bartelloni, Giacomo Bossi, Fleur Bernardi, Stella |
author_sort | Toffoli, Barbara |
collection | PubMed |
description | Background. Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD). Both of them usually activate a complex range of pathogenic pathways leading to organ damage. Here we hypothesized that dyslipidemia and diabetes could affect osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) expression in the vessels and the heart. Materials and Methods. Gene and protein expression of OPG, TRAIL, and OPG/TRAIL ratio were quantified in the aorta and the hearts of control mice, dyslipidemic mice, and diabetic mice. Results. Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio. Conclusions. This work shows that both dyslipidemia and diabetes affect OPG/TRAIL ratio in the cardiovascular system. This could contribute to the changes in circulating OPG/TRAIL which are observed in patients with diabetes and CVD. Most importantly, these changes could mediate/contribute to atherosclerosis development and cardiac remodeling. |
format | Online Article Text |
id | pubmed-5192341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51923412017-01-09 Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System Toffoli, Barbara Fabris, Bruno Bartelloni, Giacomo Bossi, Fleur Bernardi, Stella Mediators Inflamm Research Article Background. Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD). Both of them usually activate a complex range of pathogenic pathways leading to organ damage. Here we hypothesized that dyslipidemia and diabetes could affect osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) expression in the vessels and the heart. Materials and Methods. Gene and protein expression of OPG, TRAIL, and OPG/TRAIL ratio were quantified in the aorta and the hearts of control mice, dyslipidemic mice, and diabetic mice. Results. Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio. Conclusions. This work shows that both dyslipidemia and diabetes affect OPG/TRAIL ratio in the cardiovascular system. This could contribute to the changes in circulating OPG/TRAIL which are observed in patients with diabetes and CVD. Most importantly, these changes could mediate/contribute to atherosclerosis development and cardiac remodeling. Hindawi Publishing Corporation 2016 2016-12-14 /pmc/articles/PMC5192341/ /pubmed/28070143 http://dx.doi.org/10.1155/2016/6529728 Text en Copyright © 2016 Barbara Toffoli et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Toffoli, Barbara Fabris, Bruno Bartelloni, Giacomo Bossi, Fleur Bernardi, Stella Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System |
title | Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System |
title_full | Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System |
title_fullStr | Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System |
title_full_unstemmed | Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System |
title_short | Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System |
title_sort | dyslipidemia and diabetes increase the opg/trail ratio in the cardiovascular system |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192341/ https://www.ncbi.nlm.nih.gov/pubmed/28070143 http://dx.doi.org/10.1155/2016/6529728 |
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