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Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System

Background. Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD). Both of them usually activate a complex range of pathogenic pathways leading to organ damage. Here we hypothesized that dyslipidemia and diabetes could affect...

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Autores principales: Toffoli, Barbara, Fabris, Bruno, Bartelloni, Giacomo, Bossi, Fleur, Bernardi, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192341/
https://www.ncbi.nlm.nih.gov/pubmed/28070143
http://dx.doi.org/10.1155/2016/6529728
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author Toffoli, Barbara
Fabris, Bruno
Bartelloni, Giacomo
Bossi, Fleur
Bernardi, Stella
author_facet Toffoli, Barbara
Fabris, Bruno
Bartelloni, Giacomo
Bossi, Fleur
Bernardi, Stella
author_sort Toffoli, Barbara
collection PubMed
description Background. Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD). Both of them usually activate a complex range of pathogenic pathways leading to organ damage. Here we hypothesized that dyslipidemia and diabetes could affect osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) expression in the vessels and the heart. Materials and Methods. Gene and protein expression of OPG, TRAIL, and OPG/TRAIL ratio were quantified in the aorta and the hearts of control mice, dyslipidemic mice, and diabetic mice. Results. Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio. Conclusions. This work shows that both dyslipidemia and diabetes affect OPG/TRAIL ratio in the cardiovascular system. This could contribute to the changes in circulating OPG/TRAIL which are observed in patients with diabetes and CVD. Most importantly, these changes could mediate/contribute to atherosclerosis development and cardiac remodeling.
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spelling pubmed-51923412017-01-09 Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System Toffoli, Barbara Fabris, Bruno Bartelloni, Giacomo Bossi, Fleur Bernardi, Stella Mediators Inflamm Research Article Background. Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD). Both of them usually activate a complex range of pathogenic pathways leading to organ damage. Here we hypothesized that dyslipidemia and diabetes could affect osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) expression in the vessels and the heart. Materials and Methods. Gene and protein expression of OPG, TRAIL, and OPG/TRAIL ratio were quantified in the aorta and the hearts of control mice, dyslipidemic mice, and diabetic mice. Results. Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio. Conclusions. This work shows that both dyslipidemia and diabetes affect OPG/TRAIL ratio in the cardiovascular system. This could contribute to the changes in circulating OPG/TRAIL which are observed in patients with diabetes and CVD. Most importantly, these changes could mediate/contribute to atherosclerosis development and cardiac remodeling. Hindawi Publishing Corporation 2016 2016-12-14 /pmc/articles/PMC5192341/ /pubmed/28070143 http://dx.doi.org/10.1155/2016/6529728 Text en Copyright © 2016 Barbara Toffoli et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Toffoli, Barbara
Fabris, Bruno
Bartelloni, Giacomo
Bossi, Fleur
Bernardi, Stella
Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System
title Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System
title_full Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System
title_fullStr Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System
title_full_unstemmed Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System
title_short Dyslipidemia and Diabetes Increase the OPG/TRAIL Ratio in the Cardiovascular System
title_sort dyslipidemia and diabetes increase the opg/trail ratio in the cardiovascular system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192341/
https://www.ncbi.nlm.nih.gov/pubmed/28070143
http://dx.doi.org/10.1155/2016/6529728
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