Use of Cellular Decapping Activators by Positive-Strand RNA Viruses

Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses a...

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Detalles Bibliográficos
Autores principales: Jungfleisch, Jennifer, Blasco-Moreno, Bernat, Díez, Juana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192400/
https://www.ncbi.nlm.nih.gov/pubmed/28009841
http://dx.doi.org/10.3390/v8120340
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author Jungfleisch, Jennifer
Blasco-Moreno, Bernat
Díez, Juana
author_facet Jungfleisch, Jennifer
Blasco-Moreno, Bernat
Díez, Juana
author_sort Jungfleisch, Jennifer
collection PubMed
description Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5′-3′ mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus.
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spelling pubmed-51924002017-01-03 Use of Cellular Decapping Activators by Positive-Strand RNA Viruses Jungfleisch, Jennifer Blasco-Moreno, Bernat Díez, Juana Viruses Review Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5′-3′ mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus. MDPI 2016-12-21 /pmc/articles/PMC5192400/ /pubmed/28009841 http://dx.doi.org/10.3390/v8120340 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jungfleisch, Jennifer
Blasco-Moreno, Bernat
Díez, Juana
Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
title Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
title_full Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
title_fullStr Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
title_full_unstemmed Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
title_short Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
title_sort use of cellular decapping activators by positive-strand rna viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192400/
https://www.ncbi.nlm.nih.gov/pubmed/28009841
http://dx.doi.org/10.3390/v8120340
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