Cargando…

Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications

Glutamate dehydrogenase (GDH) of animal cells is usually considered to be a mitochondrial enzyme. However, this enzyme has recently been reported to be also present in nucleus, endoplasmic reticulum and lysosomes. These extramitochondrial localizations are associated with moonlighting functions of G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bunik, Victoria, Artiukhov, Artem, Aleshin, Vasily, Mkrtchyan, Garik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192433/ https://www.ncbi.nlm.nih.gov/pubmed/27983623 http://dx.doi.org/10.3390/biology5040053

Ejemplares similares

Severe Spinal Cord Injury in Rats Induces Chronic Changes in the Spinal Cord and Cerebral Cortex Metabolism, Adjusted by Thiamine That Improves Locomotor Performance
por: Boyko, Alexandra, et al.
Publicado: (2021)

Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase
por: Aleshin, Vasily A., et al.
Publicado: (2022)

Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293
por: Aleshin, Vasily A., et al.
Publicado: (2021)

Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological Responses
por: Bunik, Victoria I., et al.
Publicado: (2022)

Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age
por: Graf, Anastasia V., et al.
Publicado: (2022)

Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation
por: Artiukhov, Artem V., et al.
Publicado: (2022)

Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain
por: Artiukhov, Artem V., et al.
Publicado: (2022)

Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays
por: Aleshin, Vasily A., et al.
Publicado: (2015)

Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues
por: Artiukhov, Artem V., et al.
Publicado: (2020)

Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation
por: Boyko, Alexandra I., et al.
Publicado: (2022)

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis
por: Mkrtchyan, Garik, et al.
Publicado: (2015)

Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates
por: Artiukhov, Artem V., et al.
Publicado: (2021)

Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model
por: Aleshin, Vasily A., et al.
Publicado: (2021)

Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic Regulators in the Rat Brain
por: Aleshin, Vasily A., et al.
Publicado: (2023)

Preparation of Affinity Purified Antibodies against ε-Glutaryl-Lysine Residues in Proteins for Investigation of Glutarylated Proteins in Animal Tissues
por: Artiukhov, Artem V., et al.
Publicado: (2021)

Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death
por: Weidinger, Adelheid, et al.
Publicado: (2023)

The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy
por: Zavileyskiy, Lev G., et al.
Publicado: (2022)

Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate
por: Aleshin, Vasily A., et al.
Publicado: (2021)

Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action
por: Bunik, Victoria I., et al.
Publicado: (2020)

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells
por: Bunik, Victoria I., et al.
Publicado: (2015)

Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner
por: Bunik, Victoria I., et al.
Publicado: (2016)

Physiological Role of Glutamate Dehydrogenase in Cancer Cells
por: Moreno-Sánchez, Rafael, et al.
Publicado: (2020)

Inhibition of 2-Oxoglutarate Dehydrogenase as a Chemical Model of Acute Hypobaric Hypoxia
por: Graf, Anastasia, et al.
Publicado: (2021)

Efficient Assay and Marker Significance of NAD(+) in Human Blood
por: Balashova, Natalia V., et al.
Publicado: (2022)

Glutamate Dehydrogenase Functions in Glutamic Acid Metabolism and Stress Resistance in Pyropia haitanensis
por: Li, Shuang, et al.
Publicado: (2021)

The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
por: Fahien, Leonard A., et al.
Publicado: (2011)

Aminotransferase and glutamate dehydrogenase activities in lactobacilli and streptococci
por: Peralta, Guillermo Hugo, et al.
Publicado: (2016)

Allosteric regulation of glutamate dehydrogenase deamination activity
por: Bera, Soumen, et al.
Publicado: (2020)

Glutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment
por: Zeng, Qiao, et al.
Publicado: (2023)

Inhibitors of Glutamate Dehydrogenase Block Sodium-Dependent Glutamate Uptake in Rat Brain Membranes
por: Whitelaw, Brendan S., et al.
Publicado: (2013)

Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
por: Lorin, Séverine, et al.
Publicado: (2013)

Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases
por: Trofimova, L., et al.
Publicado: (2010)

Physiological, Biochemical, and Structural Bioinformatic Analysis of the Multiple Inositol Dehydrogenases from Corynebacterium glutamicum
por: Ramp, Paul, et al.
Publicado: (2022)

Parameterized Algorithms for Partial Vertex Covers in Bipartite Graphs
por: Mkrtchyan, Vahan, et al.
Publicado: (2020)

Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption
por: Vega Rasgado, Lourdes A., et al.
Publicado: (2012)

Importance of Glutamate Dehydrogenase (GDH) in Clostridium difficile Colonization In Vivo
por: Girinathan, Brintha Parasumanna, et al.
Publicado: (2016)

The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae
por: Mara, P., et al.
Publicado: (2018)

A Legionella effector ADP-ribosyltransferase inactivates glutamate dehydrogenase
por: Black, Miles H., et al.
Publicado: (2021)

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase
por: Vetterli, Laurène, et al.
Publicado: (2012)

Determination of Glutamate Dehydrogenase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry)
por: Botman, Dennis, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4k6rk6duq7o9anejoeavgheb2j