Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)

Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3–9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY(2) isolated from the leaves of Sonneratia apetala. Their structures were elucidated on...

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Detalles Bibliográficos
Autores principales: Liu, Hongju, Chen, Senhua, Liu, Weiyang, Liu, Yayue, Huang, Xishan, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192454/
https://www.ncbi.nlm.nih.gov/pubmed/27897975
http://dx.doi.org/10.3390/md14120217
Descripción
Sumario:Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3–9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY(2) isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC(50) values ranging from 5.9 to 9.3 μg/mL.

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