Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)

Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3–9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY(2) isolated from the leaves of Sonneratia apetala. Their structures were elucidated on...

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Detalles Bibliográficos
Autores principales: Liu, Hongju, Chen, Senhua, Liu, Weiyang, Liu, Yayue, Huang, Xishan, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192454/
https://www.ncbi.nlm.nih.gov/pubmed/27897975
http://dx.doi.org/10.3390/md14120217
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author Liu, Hongju
Chen, Senhua
Liu, Weiyang
Liu, Yayue
Huang, Xishan
She, Zhigang
author_facet Liu, Hongju
Chen, Senhua
Liu, Weiyang
Liu, Yayue
Huang, Xishan
She, Zhigang
author_sort Liu, Hongju
collection PubMed
description Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3–9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY(2) isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC(50) values ranging from 5.9 to 9.3 μg/mL.
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spelling pubmed-51924542017-01-03 Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2) Liu, Hongju Chen, Senhua Liu, Weiyang Liu, Yayue Huang, Xishan She, Zhigang Mar Drugs Article Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3–9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY(2) isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC(50) values ranging from 5.9 to 9.3 μg/mL. MDPI 2016-11-25 /pmc/articles/PMC5192454/ /pubmed/27897975 http://dx.doi.org/10.3390/md14120217 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Hongju
Chen, Senhua
Liu, Weiyang
Liu, Yayue
Huang, Xishan
She, Zhigang
Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)
title Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)
title_full Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)
title_fullStr Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)
title_full_unstemmed Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)
title_short Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY(2)
title_sort polyketides with immunosuppressive activities from mangrove endophytic fungus penicillium sp. zj-sy(2)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192454/
https://www.ncbi.nlm.nih.gov/pubmed/27897975
http://dx.doi.org/10.3390/md14120217
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