New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.

Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The...

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Autores principales: Chang, Yu-Chia, Hwang, Tsong-Long, Sheu, Jyh-Horng, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192455/
https://www.ncbi.nlm.nih.gov/pubmed/27898026
http://dx.doi.org/10.3390/md14120218
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author Chang, Yu-Chia
Hwang, Tsong-Long
Sheu, Jyh-Horng
Wu, Yang-Chang
Sung, Ping-Jyun
author_facet Chang, Yu-Chia
Hwang, Tsong-Long
Sheu, Jyh-Horng
Wu, Yang-Chang
Sung, Ping-Jyun
author_sort Chang, Yu-Chia
collection PubMed
description Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
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spelling pubmed-51924552017-01-03 New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. Chang, Yu-Chia Hwang, Tsong-Long Sheu, Jyh-Horng Wu, Yang-Chang Sung, Ping-Jyun Mar Drugs Article Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. MDPI 2016-11-26 /pmc/articles/PMC5192455/ /pubmed/27898026 http://dx.doi.org/10.3390/md14120218 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Yu-Chia
Hwang, Tsong-Long
Sheu, Jyh-Horng
Wu, Yang-Chang
Sung, Ping-Jyun
New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
title New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
title_full New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
title_fullStr New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
title_full_unstemmed New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
title_short New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
title_sort new anti-inflammatory 9,11-secosterols with a rare tricyclo[5,2,1,1]decane ring from a formosan gorgonian pinnigorgia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192455/
https://www.ncbi.nlm.nih.gov/pubmed/27898026
http://dx.doi.org/10.3390/md14120218
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