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Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer
This research was aimed at a search for regularities in changes to parameters of endogenous intoxication and saliva lipid peroxidation in patients with lung cancer, non-malignant lung diseases, and apparently healthy people. All patients went through saliva sampling at an amount of 1 mL. A concentra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192514/ https://www.ncbi.nlm.nih.gov/pubmed/27854319 http://dx.doi.org/10.3390/diagnostics6040039 |
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author | Bel’skaya, Lyudmila V. Kosenok, Victor K. Massard, Gilbert |
author_facet | Bel’skaya, Lyudmila V. Kosenok, Victor K. Massard, Gilbert |
author_sort | Bel’skaya, Lyudmila V. |
collection | PubMed |
description | This research was aimed at a search for regularities in changes to parameters of endogenous intoxication and saliva lipid peroxidation in patients with lung cancer, non-malignant lung diseases, and apparently healthy people. All patients went through saliva sampling at an amount of 1 mL. A concentration of malondialdehyde (MDA) was measured according to a reaction with thiobarbituric acid, and a level of middle molecules (MM) was measured with UV spectroscopy at 254 and 280 nm, while the content of lipid peroxidation products was measured according to a degree of heptane extract light absorption at wavelengths of 220, 232, 278, and 400 nm. It has been revealed that in the context of lung cancer, the level of diene conjugates decreases, increasing the level of triene conjugates, Schiff’s bases, and MM. As a tumor grows, there is a decrease in the level of lipid peroxidation primary products and an increase in endotoxemia phenomena. The process is more apparent when going from local to locally advanced disease states. The nature of the MDA change is nonlinearly associated with tumor progression. The findings might be used to optimize traditional aids of diagnostics, in disease state forecasting, in treatment monitoring, etc. |
format | Online Article Text |
id | pubmed-5192514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51925142017-01-03 Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer Bel’skaya, Lyudmila V. Kosenok, Victor K. Massard, Gilbert Diagnostics (Basel) Article This research was aimed at a search for regularities in changes to parameters of endogenous intoxication and saliva lipid peroxidation in patients with lung cancer, non-malignant lung diseases, and apparently healthy people. All patients went through saliva sampling at an amount of 1 mL. A concentration of malondialdehyde (MDA) was measured according to a reaction with thiobarbituric acid, and a level of middle molecules (MM) was measured with UV spectroscopy at 254 and 280 nm, while the content of lipid peroxidation products was measured according to a degree of heptane extract light absorption at wavelengths of 220, 232, 278, and 400 nm. It has been revealed that in the context of lung cancer, the level of diene conjugates decreases, increasing the level of triene conjugates, Schiff’s bases, and MM. As a tumor grows, there is a decrease in the level of lipid peroxidation primary products and an increase in endotoxemia phenomena. The process is more apparent when going from local to locally advanced disease states. The nature of the MDA change is nonlinearly associated with tumor progression. The findings might be used to optimize traditional aids of diagnostics, in disease state forecasting, in treatment monitoring, etc. MDPI 2016-11-16 /pmc/articles/PMC5192514/ /pubmed/27854319 http://dx.doi.org/10.3390/diagnostics6040039 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bel’skaya, Lyudmila V. Kosenok, Victor K. Massard, Gilbert Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer |
title | Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer |
title_full | Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer |
title_fullStr | Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer |
title_full_unstemmed | Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer |
title_short | Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer |
title_sort | endogenous intoxication and saliva lipid peroxidation in patients with lung cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192514/ https://www.ncbi.nlm.nih.gov/pubmed/27854319 http://dx.doi.org/10.3390/diagnostics6040039 |
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