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Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer

This research was aimed at a search for regularities in changes to parameters of endogenous intoxication and saliva lipid peroxidation in patients with lung cancer, non-malignant lung diseases, and apparently healthy people. All patients went through saliva sampling at an amount of 1 mL. A concentra...

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Autores principales: Bel’skaya, Lyudmila V., Kosenok, Victor K., Massard, Gilbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192514/
https://www.ncbi.nlm.nih.gov/pubmed/27854319
http://dx.doi.org/10.3390/diagnostics6040039
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author Bel’skaya, Lyudmila V.
Kosenok, Victor K.
Massard, Gilbert
author_facet Bel’skaya, Lyudmila V.
Kosenok, Victor K.
Massard, Gilbert
author_sort Bel’skaya, Lyudmila V.
collection PubMed
description This research was aimed at a search for regularities in changes to parameters of endogenous intoxication and saliva lipid peroxidation in patients with lung cancer, non-malignant lung diseases, and apparently healthy people. All patients went through saliva sampling at an amount of 1 mL. A concentration of malondialdehyde (MDA) was measured according to a reaction with thiobarbituric acid, and a level of middle molecules (MM) was measured with UV spectroscopy at 254 and 280 nm, while the content of lipid peroxidation products was measured according to a degree of heptane extract light absorption at wavelengths of 220, 232, 278, and 400 nm. It has been revealed that in the context of lung cancer, the level of diene conjugates decreases, increasing the level of triene conjugates, Schiff’s bases, and MM. As a tumor grows, there is a decrease in the level of lipid peroxidation primary products and an increase in endotoxemia phenomena. The process is more apparent when going from local to locally advanced disease states. The nature of the MDA change is nonlinearly associated with tumor progression. The findings might be used to optimize traditional aids of diagnostics, in disease state forecasting, in treatment monitoring, etc.
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spelling pubmed-51925142017-01-03 Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer Bel’skaya, Lyudmila V. Kosenok, Victor K. Massard, Gilbert Diagnostics (Basel) Article This research was aimed at a search for regularities in changes to parameters of endogenous intoxication and saliva lipid peroxidation in patients with lung cancer, non-malignant lung diseases, and apparently healthy people. All patients went through saliva sampling at an amount of 1 mL. A concentration of malondialdehyde (MDA) was measured according to a reaction with thiobarbituric acid, and a level of middle molecules (MM) was measured with UV spectroscopy at 254 and 280 nm, while the content of lipid peroxidation products was measured according to a degree of heptane extract light absorption at wavelengths of 220, 232, 278, and 400 nm. It has been revealed that in the context of lung cancer, the level of diene conjugates decreases, increasing the level of triene conjugates, Schiff’s bases, and MM. As a tumor grows, there is a decrease in the level of lipid peroxidation primary products and an increase in endotoxemia phenomena. The process is more apparent when going from local to locally advanced disease states. The nature of the MDA change is nonlinearly associated with tumor progression. The findings might be used to optimize traditional aids of diagnostics, in disease state forecasting, in treatment monitoring, etc. MDPI 2016-11-16 /pmc/articles/PMC5192514/ /pubmed/27854319 http://dx.doi.org/10.3390/diagnostics6040039 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bel’skaya, Lyudmila V.
Kosenok, Victor K.
Massard, Gilbert
Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer
title Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer
title_full Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer
title_fullStr Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer
title_full_unstemmed Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer
title_short Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer
title_sort endogenous intoxication and saliva lipid peroxidation in patients with lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192514/
https://www.ncbi.nlm.nih.gov/pubmed/27854319
http://dx.doi.org/10.3390/diagnostics6040039
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