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The role of microRNAs in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy with poor prognosis. Despite improvements in its diagnosis and therapy, the prognosis for ICC patients remains poor. An improved understanding of ICC pathogenesis and consequential identification of novel ther...

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Detalles Bibliográficos
Autores principales: Li, Zheng, Shen, Jianxiong, Chan, Matthew T.V., Wu, William Ka Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192883/
https://www.ncbi.nlm.nih.gov/pubmed/27619971
http://dx.doi.org/10.1111/jcmm.12951
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author Li, Zheng
Shen, Jianxiong
Chan, Matthew T.V.
Wu, William Ka Kei
author_facet Li, Zheng
Shen, Jianxiong
Chan, Matthew T.V.
Wu, William Ka Kei
author_sort Li, Zheng
collection PubMed
description Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy with poor prognosis. Despite improvements in its diagnosis and therapy, the prognosis for ICC patients remains poor. An improved understanding of ICC pathogenesis and consequential identification of novel therapeutic targets would improve the prognosis of ICC patients. MicroRNAs (miRNAs) are a class of highly conserved, endogenous, small non‐coding RNA molecules of 18–23 nucleotides in length, which regulate gene expression through complementary base‐pairing with target messenger RNAs and subsequent gene silencing. Several studies have shown deregulated expression of miRNAs in ICC cell lines and tissues, in which these miRNAs play important roles in ICC apoptosis, cell proliferation, invasion, migration and metastasis. In this review, we illustrate the potential role of miRNA in the pathogenesis of ICC and explore the possibilities of using miRNAs as prognostic and diagnostic markers, as well as therapeutic targets in ICC.
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spelling pubmed-51928832017-01-01 The role of microRNAs in intrahepatic cholangiocarcinoma Li, Zheng Shen, Jianxiong Chan, Matthew T.V. Wu, William Ka Kei J Cell Mol Med Reviews Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy with poor prognosis. Despite improvements in its diagnosis and therapy, the prognosis for ICC patients remains poor. An improved understanding of ICC pathogenesis and consequential identification of novel therapeutic targets would improve the prognosis of ICC patients. MicroRNAs (miRNAs) are a class of highly conserved, endogenous, small non‐coding RNA molecules of 18–23 nucleotides in length, which regulate gene expression through complementary base‐pairing with target messenger RNAs and subsequent gene silencing. Several studies have shown deregulated expression of miRNAs in ICC cell lines and tissues, in which these miRNAs play important roles in ICC apoptosis, cell proliferation, invasion, migration and metastasis. In this review, we illustrate the potential role of miRNA in the pathogenesis of ICC and explore the possibilities of using miRNAs as prognostic and diagnostic markers, as well as therapeutic targets in ICC. John Wiley and Sons Inc. 2016-09-13 2017-01 /pmc/articles/PMC5192883/ /pubmed/27619971 http://dx.doi.org/10.1111/jcmm.12951 Text en © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Li, Zheng
Shen, Jianxiong
Chan, Matthew T.V.
Wu, William Ka Kei
The role of microRNAs in intrahepatic cholangiocarcinoma
title The role of microRNAs in intrahepatic cholangiocarcinoma
title_full The role of microRNAs in intrahepatic cholangiocarcinoma
title_fullStr The role of microRNAs in intrahepatic cholangiocarcinoma
title_full_unstemmed The role of microRNAs in intrahepatic cholangiocarcinoma
title_short The role of microRNAs in intrahepatic cholangiocarcinoma
title_sort role of micrornas in intrahepatic cholangiocarcinoma
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192883/
https://www.ncbi.nlm.nih.gov/pubmed/27619971
http://dx.doi.org/10.1111/jcmm.12951
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