Integrated Two‐Analyte Population Pharmacokinetic Model for Antibody–Drug Conjugates in Patients: Implications for Reducing Pharmacokinetic Sampling

An integrated pharmacokinetics (PK) model that simultaneously describes concentrations of total antibody (Tab) and antibody‐conjugated monomethyl auristatin E (acMMAE) following administration of monomethyl auristatin E (MMAE)‐containing antibody–drug conjugates (ADCs) was developed based on phase I...

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Detalles Bibliográficos
Autores principales: Lu, D, Gibiansky, L, Agarwal, P, Dere, RC, Li, C, Chu, Y‐W, Hirata, J, Joshi, A, Jin, JY, Girish, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192970/
https://www.ncbi.nlm.nih.gov/pubmed/27863168
http://dx.doi.org/10.1002/psp4.12137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192970/
https://www.ncbi.nlm.nih.gov/pubmed/27863168
http://dx.doi.org/10.1002/psp4.12137

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