A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics

The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated...

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Detalles Bibliográficos
Autor principal: Duffull, SB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192992/
https://www.ncbi.nlm.nih.gov/pubmed/27863137
http://dx.doi.org/10.1002/psp4.12148
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author Duffull, SB
author_facet Duffull, SB
author_sort Duffull, SB
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description The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits into the overall scientific approach.
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spelling pubmed-51929922016-12-29 A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics Duffull, SB CPT Pharmacometrics Syst Pharmacol Review The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits into the overall scientific approach. John Wiley and Sons Inc. 2016-11-12 2016-12 /pmc/articles/PMC5192992/ /pubmed/27863137 http://dx.doi.org/10.1002/psp4.12148 Text en © 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Duffull, SB
A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
title A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
title_full A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
title_fullStr A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
title_full_unstemmed A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
title_short A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
title_sort philosophical framework for integrating systems pharmacology models into pharmacometrics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192992/
https://www.ncbi.nlm.nih.gov/pubmed/27863137
http://dx.doi.org/10.1002/psp4.12148
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