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Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma

BACKGROUND: Perineural invasion has been found in several types of human tumors, and is associated with poor prognosis; however, few studies have examined perineural invasion in lung cancer. We evaluated the relationship between autonomic nervous densities, pathological risk grading, and prognosis i...

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Autores principales: Shao, Jing‐Xin, Wang, Bo, Yao, Yi‐Nan, Pan, Zhi‐Jie, Shen, Qian, Zhou, Jian‐Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193011/
https://www.ncbi.nlm.nih.gov/pubmed/27766778
http://dx.doi.org/10.1111/1759-7714.12374
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author Shao, Jing‐Xin
Wang, Bo
Yao, Yi‐Nan
Pan, Zhi‐Jie
Shen, Qian
Zhou, Jian‐Ying
author_facet Shao, Jing‐Xin
Wang, Bo
Yao, Yi‐Nan
Pan, Zhi‐Jie
Shen, Qian
Zhou, Jian‐Ying
author_sort Shao, Jing‐Xin
collection PubMed
description BACKGROUND: Perineural invasion has been found in several types of human tumors, and is associated with poor prognosis; however, few studies have examined perineural invasion in lung cancer. We evaluated the relationship between autonomic nervous densities, pathological risk grading, and prognosis in patients with lung adenocarcinoma (LADC). METHODS: Neural fiber expression was examined by immunofluorescence in resected lung specimens in control patients (n = 30), and low‐risk (n = 22), and high‐risk LADC patients (n = 43). The nerve densities of normal lung tissue and abnormal lung tissues in the tumor and surrounding tissues were evaluated by a semi‐quantitative score method. RESULTS: Increased sympathetic fibers mainly infiltrated the paratumoral area, while increased parasympathetic fibers were largely restricted to the tumor (paratumor vs. tumor, P = 0.000 in high, P = 0.034 in low; each). In addition, high‐risk patients presented the highest density of neural fibers, followed by low‐risk and control patients (P = 0.000; each). In Kaplan–Meier survival analysis, the densities of sympathetic fibers in paratumoral tissue and parasympathetic fibers in the tumor, respectively, correlated with poor recurrence‐free survival in patients who were not treated with adjuvant therapy (P < 0.001; each). Further multivariate analysis showed that these two factors were associated with poor prognosis in all LADC patients (P = 0.024 sympathetic fibers; P = 0.037 parasympathetic fibers). CONCLUSION: These findings reveal a positive correlation between nervous infiltration and risk of poor prognosis in patients with LADC.
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spelling pubmed-51930112016-12-29 Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma Shao, Jing‐Xin Wang, Bo Yao, Yi‐Nan Pan, Zhi‐Jie Shen, Qian Zhou, Jian‐Ying Thorac Cancer Original Articles BACKGROUND: Perineural invasion has been found in several types of human tumors, and is associated with poor prognosis; however, few studies have examined perineural invasion in lung cancer. We evaluated the relationship between autonomic nervous densities, pathological risk grading, and prognosis in patients with lung adenocarcinoma (LADC). METHODS: Neural fiber expression was examined by immunofluorescence in resected lung specimens in control patients (n = 30), and low‐risk (n = 22), and high‐risk LADC patients (n = 43). The nerve densities of normal lung tissue and abnormal lung tissues in the tumor and surrounding tissues were evaluated by a semi‐quantitative score method. RESULTS: Increased sympathetic fibers mainly infiltrated the paratumoral area, while increased parasympathetic fibers were largely restricted to the tumor (paratumor vs. tumor, P = 0.000 in high, P = 0.034 in low; each). In addition, high‐risk patients presented the highest density of neural fibers, followed by low‐risk and control patients (P = 0.000; each). In Kaplan–Meier survival analysis, the densities of sympathetic fibers in paratumoral tissue and parasympathetic fibers in the tumor, respectively, correlated with poor recurrence‐free survival in patients who were not treated with adjuvant therapy (P < 0.001; each). Further multivariate analysis showed that these two factors were associated with poor prognosis in all LADC patients (P = 0.024 sympathetic fibers; P = 0.037 parasympathetic fibers). CONCLUSION: These findings reveal a positive correlation between nervous infiltration and risk of poor prognosis in patients with LADC. John Wiley & Sons Australia, Ltd 2016-07-12 2016-09 /pmc/articles/PMC5193011/ /pubmed/27766778 http://dx.doi.org/10.1111/1759-7714.12374 Text en © 2016 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Shao, Jing‐Xin
Wang, Bo
Yao, Yi‐Nan
Pan, Zhi‐Jie
Shen, Qian
Zhou, Jian‐Ying
Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
title Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
title_full Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
title_fullStr Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
title_full_unstemmed Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
title_short Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
title_sort autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193011/
https://www.ncbi.nlm.nih.gov/pubmed/27766778
http://dx.doi.org/10.1111/1759-7714.12374
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