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Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study

Objective: A retrospective study was performed to compare the difference in platelet count (PLT), prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (APTT), between cirrhotic patients with and without acute upper gastrointestinal bleeding (AUGIB) o...

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Autores principales: Li, Jing, Qi, Xingshun, Deng, Han, Peng, Ying, Shao, Lichun, Ma, Jiaxin, Sun, Xiaolin, Li, Hongyu, Guo, Xiaozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193061/
https://www.ncbi.nlm.nih.gov/pubmed/26672007
http://dx.doi.org/10.1093/gastro/gov059
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author Li, Jing
Qi, Xingshun
Deng, Han
Peng, Ying
Shao, Lichun
Ma, Jiaxin
Sun, Xiaolin
Li, Hongyu
Guo, Xiaozhong
author_facet Li, Jing
Qi, Xingshun
Deng, Han
Peng, Ying
Shao, Lichun
Ma, Jiaxin
Sun, Xiaolin
Li, Hongyu
Guo, Xiaozhong
author_sort Li, Jing
collection PubMed
description Objective: A retrospective study was performed to compare the difference in platelet count (PLT), prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (APTT), between cirrhotic patients with and without acute upper gastrointestinal bleeding (AUGIB) or acute oesophageal variceal bleeding (AEVB). Methods: Between January 2012 and June 2014, a total of 1734 cirrhotic patients were enrolled and were classified into ‘AUGIB’ (n = 497) and ‘no AUGIB’ (n = 1237) groups according to their disease history. They were further divided into ‘AEVB’ (n = 297) and ‘no AEVB’ (n = 1259) groups according to the endoscopic findings. Additionally, 178 patients with AUGIB were not assigned to either the ‘AEVB’ or ‘no AEVB’ groups due to the absence of any endoscopic findings. Results: Compared with the ‘no AUGIB’ group, the ‘AUGIB’ group had similar PLT (99.99 ± 89.90 vs.101.47 ± 83.03; P = 0.734) and APTT (42.96 ± 15.20 vs.43.77 ± 11.01; P = 0.219), but significantly higher PT (17.30 ± 5.62 vs.16.03 ± 4.68; P < 0.001) and INR (1.45 ± 0.69 vs.1.31 ± 0.59; P < 0.001). A lower PT was independently associated with the absence of AUGIB (OR = 0.968; 95% CI: 0.942–0.994). Compared with the ‘no AEVB’ group, the ‘AEVB’ group had significantly lower PLT (86.87 ± 62.14 vs.101.74 ± 83.62; P = 0.004) and APTT (40.98 ± 7.9 vs.43.72 ± 10.97; P < 0.001), but similar PT (16.53 ± 3.71 vs.16.04 ± 4.68; P = 0.088) and INR (1.35 ± 0.41 vs.1.31 ± 0.59; P = 0.225). A higher PLT was independently associated with the absence of AEVB (OR = 1.004; 95% CI: 1.002–1.006; P = 0.001). Conclusions: PLT was associated with the occurrence of portal hypertension-related bleeding in liver cirrhosis.
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spelling pubmed-51930612017-01-04 Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study Li, Jing Qi, Xingshun Deng, Han Peng, Ying Shao, Lichun Ma, Jiaxin Sun, Xiaolin Li, Hongyu Guo, Xiaozhong Gastroenterol Rep (Oxf) Original Articles Objective: A retrospective study was performed to compare the difference in platelet count (PLT), prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (APTT), between cirrhotic patients with and without acute upper gastrointestinal bleeding (AUGIB) or acute oesophageal variceal bleeding (AEVB). Methods: Between January 2012 and June 2014, a total of 1734 cirrhotic patients were enrolled and were classified into ‘AUGIB’ (n = 497) and ‘no AUGIB’ (n = 1237) groups according to their disease history. They were further divided into ‘AEVB’ (n = 297) and ‘no AEVB’ (n = 1259) groups according to the endoscopic findings. Additionally, 178 patients with AUGIB were not assigned to either the ‘AEVB’ or ‘no AEVB’ groups due to the absence of any endoscopic findings. Results: Compared with the ‘no AUGIB’ group, the ‘AUGIB’ group had similar PLT (99.99 ± 89.90 vs.101.47 ± 83.03; P = 0.734) and APTT (42.96 ± 15.20 vs.43.77 ± 11.01; P = 0.219), but significantly higher PT (17.30 ± 5.62 vs.16.03 ± 4.68; P < 0.001) and INR (1.45 ± 0.69 vs.1.31 ± 0.59; P < 0.001). A lower PT was independently associated with the absence of AUGIB (OR = 0.968; 95% CI: 0.942–0.994). Compared with the ‘no AEVB’ group, the ‘AEVB’ group had significantly lower PLT (86.87 ± 62.14 vs.101.74 ± 83.62; P = 0.004) and APTT (40.98 ± 7.9 vs.43.72 ± 10.97; P < 0.001), but similar PT (16.53 ± 3.71 vs.16.04 ± 4.68; P = 0.088) and INR (1.35 ± 0.41 vs.1.31 ± 0.59; P = 0.225). A higher PLT was independently associated with the absence of AEVB (OR = 1.004; 95% CI: 1.002–1.006; P = 0.001). Conclusions: PLT was associated with the occurrence of portal hypertension-related bleeding in liver cirrhosis. Oxford University Press 2016-11 2015-12-15 /pmc/articles/PMC5193061/ /pubmed/26672007 http://dx.doi.org/10.1093/gastro/gov059 Text en © The Author(s) 2015. Published by Oxford University Press and the Digestive Science Publishing Co. Limited. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Li, Jing
Qi, Xingshun
Deng, Han
Peng, Ying
Shao, Lichun
Ma, Jiaxin
Sun, Xiaolin
Li, Hongyu
Guo, Xiaozhong
Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study
title Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study
title_full Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study
title_fullStr Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study
title_full_unstemmed Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study
title_short Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study
title_sort association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193061/
https://www.ncbi.nlm.nih.gov/pubmed/26672007
http://dx.doi.org/10.1093/gastro/gov059
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