An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methy...

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Detalles Bibliográficos
Autores principales: Svensson, Kjell A., Heinz, Beverly A., Schaus, John M., Beck, James P., Hao, Junliang, Krushinski, Joseph H., Reinhard, Matthew R., Cohen, Michael P., Hellman, Sarah L., Getman, Brian G., Wang, Xushan, Menezes, Michelle M., Maren, Deanna L., Falcone, Julie F., Anderson, Wesley H., Wright, Rebecca A., Morin, S. Michelle, Knopp, Kelly L., Adams, Benjamin L., Rogovoy, Borys, Okun, Ilya, Suter, Todd M., Statnick, Michael A., Gehlert, Donald R., Nelson, David L., Lucaites, Virginia L., Emkey, Renee, DeLapp, Neil W., Wiernicki, Todd R., Cramer, Jeffrey W., Yang, Charles R., Bruns, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:
Neuropharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193077/
https://www.ncbi.nlm.nih.gov/pubmed/27811173
http://dx.doi.org/10.1124/jpet.116.236372

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