Zika Virus Causing Encephalomyelitis Associated With Immunoactivation

Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperinte...

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Autores principales: Galliez, Rafael Mello, Spitz, Mariana, Rafful, Patricia Piazza, Cagy, Marcelo, Escosteguy, Claudia, Germano, Caroline Spósito Brito, Sasse, Elisa, Gonçalves, Alessandro Luis, Silveira, Paola Paz, Pezzuto, Paula, Ornelas, Alice Maria de Magalhães, Tanuri, Amilcar, Aguiar, Renato Santana, Moll, Fernanda Tovar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193179/
https://www.ncbi.nlm.nih.gov/pubmed/28053996
http://dx.doi.org/10.1093/ofid/ofw203
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author Galliez, Rafael Mello
Spitz, Mariana
Rafful, Patricia Piazza
Cagy, Marcelo
Escosteguy, Claudia
Germano, Caroline Spósito Brito
Sasse, Elisa
Gonçalves, Alessandro Luis
Silveira, Paola Paz
Pezzuto, Paula
Ornelas, Alice Maria de Magalhães
Tanuri, Amilcar
Aguiar, Renato Santana
Moll, Fernanda Tovar
author_facet Galliez, Rafael Mello
Spitz, Mariana
Rafful, Patricia Piazza
Cagy, Marcelo
Escosteguy, Claudia
Germano, Caroline Spósito Brito
Sasse, Elisa
Gonçalves, Alessandro Luis
Silveira, Paola Paz
Pezzuto, Paula
Ornelas, Alice Maria de Magalhães
Tanuri, Amilcar
Aguiar, Renato Santana
Moll, Fernanda Tovar
author_sort Galliez, Rafael Mello
collection PubMed
description Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase. This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation.
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spelling pubmed-51931792017-01-04 Zika Virus Causing Encephalomyelitis Associated With Immunoactivation Galliez, Rafael Mello Spitz, Mariana Rafful, Patricia Piazza Cagy, Marcelo Escosteguy, Claudia Germano, Caroline Spósito Brito Sasse, Elisa Gonçalves, Alessandro Luis Silveira, Paola Paz Pezzuto, Paula Ornelas, Alice Maria de Magalhães Tanuri, Amilcar Aguiar, Renato Santana Moll, Fernanda Tovar Open Forum Infect Dis Brief Report Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase. This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation. Oxford University Press 2016-10-03 /pmc/articles/PMC5193179/ /pubmed/28053996 http://dx.doi.org/10.1093/ofid/ofw203 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Report
Galliez, Rafael Mello
Spitz, Mariana
Rafful, Patricia Piazza
Cagy, Marcelo
Escosteguy, Claudia
Germano, Caroline Spósito Brito
Sasse, Elisa
Gonçalves, Alessandro Luis
Silveira, Paola Paz
Pezzuto, Paula
Ornelas, Alice Maria de Magalhães
Tanuri, Amilcar
Aguiar, Renato Santana
Moll, Fernanda Tovar
Zika Virus Causing Encephalomyelitis Associated With Immunoactivation
title Zika Virus Causing Encephalomyelitis Associated With Immunoactivation
title_full Zika Virus Causing Encephalomyelitis Associated With Immunoactivation
title_fullStr Zika Virus Causing Encephalomyelitis Associated With Immunoactivation
title_full_unstemmed Zika Virus Causing Encephalomyelitis Associated With Immunoactivation
title_short Zika Virus Causing Encephalomyelitis Associated With Immunoactivation
title_sort zika virus causing encephalomyelitis associated with immunoactivation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193179/
https://www.ncbi.nlm.nih.gov/pubmed/28053996
http://dx.doi.org/10.1093/ofid/ofw203
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