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Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions
The Hedgehog pathway is a potent regulator of cellular growth and plays a central role in the development of many cancers including basal cell carcinoma (BCC). The majority of BCCs arise from mutations in the Patched receptor resulting in constitutive activation of the Hedgehog pathway. Secondary dr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193403/ https://www.ncbi.nlm.nih.gov/pubmed/28030567 http://dx.doi.org/10.1371/journal.pone.0168031 |