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Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for hair cell mechanotransduction. We questioned...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193441/ https://www.ncbi.nlm.nih.gov/pubmed/28030585 http://dx.doi.org/10.1371/journal.pone.0168953 |
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author | Liu, Huizhan Li, Yi Chen, Lei Zhang, Qian Pan, Ning Nichols, David H. Zhang, Weiping J. Fritzsch, Bernd He, David Z. Z. |
author_facet | Liu, Huizhan Li, Yi Chen, Lei Zhang, Qian Pan, Ning Nichols, David H. Zhang, Weiping J. Fritzsch, Bernd He, David Z. Z. |
author_sort | Liu, Huizhan |
collection | PubMed |
description | Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for hair cell mechanotransduction. We questioned whether hair cells and the stria interdepend for survival by using two mouse models. Atoh1 conditional knockout mice, which lose all hair cells within four weeks after birth, were used to determine whether the absence of hair cells would affect function and survival of stria. We showed that stria morphology and EP remained normal for long time despite a complete loss of all hair cells. We then used a mouse model that has an abnormal stria morphology and function due to mutation of the Mitf gene to determine whether hair cells are able to survive and transduce sound signals without a normal electrochemical environment in the endolymph. A strial defect, reflected by missing intermediate cells in the stria and by reduction of EP, led to systematic outer hair cell death from the base to the apex after postnatal day 18. However, an 18-mV EP was sufficient for outer hair cell survival. Surprisingly, inner hair cell survival was less vulnerable to reduction of the EP. Our studies show that normal function of the stria is essential for adult outer hair cell survival, while the survival and normal function of the stria vascularis do not depend on functional hair cells. |
format | Online Article Text |
id | pubmed-5193441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-51934412017-01-19 Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? Liu, Huizhan Li, Yi Chen, Lei Zhang, Qian Pan, Ning Nichols, David H. Zhang, Weiping J. Fritzsch, Bernd He, David Z. Z. PLoS One Research Article Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for hair cell mechanotransduction. We questioned whether hair cells and the stria interdepend for survival by using two mouse models. Atoh1 conditional knockout mice, which lose all hair cells within four weeks after birth, were used to determine whether the absence of hair cells would affect function and survival of stria. We showed that stria morphology and EP remained normal for long time despite a complete loss of all hair cells. We then used a mouse model that has an abnormal stria morphology and function due to mutation of the Mitf gene to determine whether hair cells are able to survive and transduce sound signals without a normal electrochemical environment in the endolymph. A strial defect, reflected by missing intermediate cells in the stria and by reduction of EP, led to systematic outer hair cell death from the base to the apex after postnatal day 18. However, an 18-mV EP was sufficient for outer hair cell survival. Surprisingly, inner hair cell survival was less vulnerable to reduction of the EP. Our studies show that normal function of the stria is essential for adult outer hair cell survival, while the survival and normal function of the stria vascularis do not depend on functional hair cells. Public Library of Science 2016-12-28 /pmc/articles/PMC5193441/ /pubmed/28030585 http://dx.doi.org/10.1371/journal.pone.0168953 Text en © 2016 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liu, Huizhan Li, Yi Chen, Lei Zhang, Qian Pan, Ning Nichols, David H. Zhang, Weiping J. Fritzsch, Bernd He, David Z. Z. Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? |
title | Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? |
title_full | Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? |
title_fullStr | Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? |
title_full_unstemmed | Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? |
title_short | Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? |
title_sort | organ of corti and stria vascularis: is there an interdependence for survival? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193441/ https://www.ncbi.nlm.nih.gov/pubmed/28030585 http://dx.doi.org/10.1371/journal.pone.0168953 |
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