Cargando…

Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice

Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-re...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jaehyun, Ko, Hyoung-Gon, Kim, Kyungjin, Kaang, Bong-Kiun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195820/
https://www.ncbi.nlm.nih.gov/pubmed/28035185
http://dx.doi.org/10.5607/en.2016.25.6.342
_version_ 1782488416198328320
author Lee, Jaehyun
Ko, Hyoung-Gon
Kim, Kyungjin
Kaang, Bong-Kiun
author_facet Lee, Jaehyun
Ko, Hyoung-Gon
Kim, Kyungjin
Kaang, Bong-Kiun
author_sort Lee, Jaehyun
collection PubMed
description Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.
format Online
Article
Text
id pubmed-5195820
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Korean Society for Brain and Neural Science
record_format MEDLINE/PubMed
spelling pubmed-51958202016-12-29 Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice Lee, Jaehyun Ko, Hyoung-Gon Kim, Kyungjin Kaang, Bong-Kiun Exp Neurobiol Rapid Communication Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm. The Korean Society for Brain and Neural Science 2016-12 2016-11-23 /pmc/articles/PMC5195820/ /pubmed/28035185 http://dx.doi.org/10.5607/en.2016.25.6.342 Text en Copyright © Experimental Neurobiology 2016. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Rapid Communication
Lee, Jaehyun
Ko, Hyoung-Gon
Kim, Kyungjin
Kaang, Bong-Kiun
Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
title Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
title_full Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
title_fullStr Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
title_full_unstemmed Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
title_short Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
title_sort mildly increased mechanical nociceptive sensitivity in rev-erbα knock-out mice
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195820/
https://www.ncbi.nlm.nih.gov/pubmed/28035185
http://dx.doi.org/10.5607/en.2016.25.6.342
work_keys_str_mv AT leejaehyun mildlyincreasedmechanicalnociceptivesensitivityinreverbaknockoutmice
AT kohyounggon mildlyincreasedmechanicalnociceptivesensitivityinreverbaknockoutmice
AT kimkyungjin mildlyincreasedmechanicalnociceptivesensitivityinreverbaknockoutmice
AT kaangbongkiun mildlyincreasedmechanicalnociceptivesensitivityinreverbaknockoutmice