Knock out of the NADPH oxidase Nox4 has no impact on life span in mice

The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyze...

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Autores principales: Rezende, Flavia, Schürmann, Christoph, Schütz, Susanne, Harenkamp, Sabine, Herrmann, Eva, Seimetz, Michael, Weißmann, Norbert, Schröder, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196091/
https://www.ncbi.nlm.nih.gov/pubmed/28038425
http://dx.doi.org/10.1016/j.redox.2016.12.012
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author Rezende, Flavia
Schürmann, Christoph
Schütz, Susanne
Harenkamp, Sabine
Herrmann, Eva
Seimetz, Michael
Weißmann, Norbert
Schröder, Katrin
author_facet Rezende, Flavia
Schürmann, Christoph
Schütz, Susanne
Harenkamp, Sabine
Herrmann, Eva
Seimetz, Michael
Weißmann, Norbert
Schröder, Katrin
author_sort Rezende, Flavia
collection PubMed
description The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice.
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spelling pubmed-51960912017-01-04 Knock out of the NADPH oxidase Nox4 has no impact on life span in mice Rezende, Flavia Schürmann, Christoph Schütz, Susanne Harenkamp, Sabine Herrmann, Eva Seimetz, Michael Weißmann, Norbert Schröder, Katrin Redox Biol Research Paper The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice. Elsevier 2016-12-22 /pmc/articles/PMC5196091/ /pubmed/28038425 http://dx.doi.org/10.1016/j.redox.2016.12.012 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Rezende, Flavia
Schürmann, Christoph
Schütz, Susanne
Harenkamp, Sabine
Herrmann, Eva
Seimetz, Michael
Weißmann, Norbert
Schröder, Katrin
Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
title Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
title_full Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
title_fullStr Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
title_full_unstemmed Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
title_short Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
title_sort knock out of the nadph oxidase nox4 has no impact on life span in mice
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196091/
https://www.ncbi.nlm.nih.gov/pubmed/28038425
http://dx.doi.org/10.1016/j.redox.2016.12.012
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