Cargando…

Chagas disease research and development: Is there light at the end of the tunnel?

Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration. Although it was first identified more than a century ago, only two old drugs are available for treatment a...

Descripción completa

Detalles Bibliográficos
Autor principal: Chatelain, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196238/
https://www.ncbi.nlm.nih.gov/pubmed/28066534
http://dx.doi.org/10.1016/j.csbj.2016.12.002
_version_ 1782488482048901120
author Chatelain, Eric
author_facet Chatelain, Eric
author_sort Chatelain, Eric
collection PubMed
description Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration. Although it was first identified more than a century ago, only two old drugs are available for treatment and a lot of questions related to the disease progression, its pathologies, and not to mention the assessment of treatment efficacy, are subject to debate and remain to be answered. Indeed, the current status of evidence and data available does not allow any absolute statement related to treatment needs and outcome for Chagas patients to be made. Although there has been some new impetus in Research and Development for Chagas disease following recent new clinical trials, there is a scientific requirement to review and challenge the current status of evidence and define basic and clinical research priorities and next steps in the field. This should ensure that the best drugs for Chagas disease are developed, but will require a focused and collaborative effort of the entire Chagas disease research community.
format Online
Article
Text
id pubmed-5196238
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Research Network of Computational and Structural Biotechnology
record_format MEDLINE/PubMed
spelling pubmed-51962382017-01-06 Chagas disease research and development: Is there light at the end of the tunnel? Chatelain, Eric Comput Struct Biotechnol J Short Survey Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration. Although it was first identified more than a century ago, only two old drugs are available for treatment and a lot of questions related to the disease progression, its pathologies, and not to mention the assessment of treatment efficacy, are subject to debate and remain to be answered. Indeed, the current status of evidence and data available does not allow any absolute statement related to treatment needs and outcome for Chagas patients to be made. Although there has been some new impetus in Research and Development for Chagas disease following recent new clinical trials, there is a scientific requirement to review and challenge the current status of evidence and define basic and clinical research priorities and next steps in the field. This should ensure that the best drugs for Chagas disease are developed, but will require a focused and collaborative effort of the entire Chagas disease research community. Research Network of Computational and Structural Biotechnology 2016-12-14 /pmc/articles/PMC5196238/ /pubmed/28066534 http://dx.doi.org/10.1016/j.csbj.2016.12.002 Text en © 2016 The Author http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Survey
Chatelain, Eric
Chagas disease research and development: Is there light at the end of the tunnel?
title Chagas disease research and development: Is there light at the end of the tunnel?
title_full Chagas disease research and development: Is there light at the end of the tunnel?
title_fullStr Chagas disease research and development: Is there light at the end of the tunnel?
title_full_unstemmed Chagas disease research and development: Is there light at the end of the tunnel?
title_short Chagas disease research and development: Is there light at the end of the tunnel?
title_sort chagas disease research and development: is there light at the end of the tunnel?
topic Short Survey
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196238/
https://www.ncbi.nlm.nih.gov/pubmed/28066534
http://dx.doi.org/10.1016/j.csbj.2016.12.002
work_keys_str_mv AT chatelaineric chagasdiseaseresearchanddevelopmentistherelightattheendofthetunnel