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Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

The blood-brain barrier (BBB) is an obstacle for antibody passage into the brain, impeding the development of immunotherapy and antibody-based diagnostics for brain disorders. In the present study, we have developed a brain shuttle for active transport of antibodies across the BBB by receptor-mediat...

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Detalles Bibliográficos
Autores principales:	Hultqvist, Greta, Syvänen, Stina, Fang, Xiaotian T, Lannfelt, Lars, Sehlin, Dag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197066/ https://www.ncbi.nlm.nih.gov/pubmed/28042336 http://dx.doi.org/10.7150/thno.17155

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