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Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197988/ https://www.ncbi.nlm.nih.gov/pubmed/27869709 http://dx.doi.org/10.3390/jfb7040029 |
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author | Abutarboush, Rania Saha, Biswajit K. Mullah, Saad H. Arnaud, Francoise G. Haque, Ashraful Aligbe, Chioma Pappas, Georgina Auker, Charles R. McCarron, Richard M. Moon-Massat, Paula F. Scultetus, Anke H. |
author_facet | Abutarboush, Rania Saha, Biswajit K. Mullah, Saad H. Arnaud, Francoise G. Haque, Ashraful Aligbe, Chioma Pappas, Georgina Auker, Charles R. McCarron, Richard M. Moon-Massat, Paula F. Scultetus, Anke H. |
author_sort | Abutarboush, Rania |
collection | PubMed |
description | Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50–100 μm) showed minor (~8–9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend. |
format | Online Article Text |
id | pubmed-5197988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51979882017-01-04 Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran Abutarboush, Rania Saha, Biswajit K. Mullah, Saad H. Arnaud, Francoise G. Haque, Ashraful Aligbe, Chioma Pappas, Georgina Auker, Charles R. McCarron, Richard M. Moon-Massat, Paula F. Scultetus, Anke H. J Funct Biomater Article Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50–100 μm) showed minor (~8–9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend. MDPI 2016-11-18 /pmc/articles/PMC5197988/ /pubmed/27869709 http://dx.doi.org/10.3390/jfb7040029 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Abutarboush, Rania Saha, Biswajit K. Mullah, Saad H. Arnaud, Francoise G. Haque, Ashraful Aligbe, Chioma Pappas, Georgina Auker, Charles R. McCarron, Richard M. Moon-Massat, Paula F. Scultetus, Anke H. Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran |
title | Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran |
title_full | Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran |
title_fullStr | Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran |
title_full_unstemmed | Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran |
title_short | Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran |
title_sort | cerebral microvascular and systemic effects following intravenous administration of the perfluorocarbon emulsion perftoran |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197988/ https://www.ncbi.nlm.nih.gov/pubmed/27869709 http://dx.doi.org/10.3390/jfb7040029 |
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