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Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran

Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the p...

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Autores principales: Abutarboush, Rania, Saha, Biswajit K., Mullah, Saad H., Arnaud, Francoise G., Haque, Ashraful, Aligbe, Chioma, Pappas, Georgina, Auker, Charles R., McCarron, Richard M., Moon-Massat, Paula F., Scultetus, Anke H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197988/
https://www.ncbi.nlm.nih.gov/pubmed/27869709
http://dx.doi.org/10.3390/jfb7040029
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author Abutarboush, Rania
Saha, Biswajit K.
Mullah, Saad H.
Arnaud, Francoise G.
Haque, Ashraful
Aligbe, Chioma
Pappas, Georgina
Auker, Charles R.
McCarron, Richard M.
Moon-Massat, Paula F.
Scultetus, Anke H.
author_facet Abutarboush, Rania
Saha, Biswajit K.
Mullah, Saad H.
Arnaud, Francoise G.
Haque, Ashraful
Aligbe, Chioma
Pappas, Georgina
Auker, Charles R.
McCarron, Richard M.
Moon-Massat, Paula F.
Scultetus, Anke H.
author_sort Abutarboush, Rania
collection PubMed
description Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50–100 μm) showed minor (~8–9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend.
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spelling pubmed-51979882017-01-04 Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran Abutarboush, Rania Saha, Biswajit K. Mullah, Saad H. Arnaud, Francoise G. Haque, Ashraful Aligbe, Chioma Pappas, Georgina Auker, Charles R. McCarron, Richard M. Moon-Massat, Paula F. Scultetus, Anke H. J Funct Biomater Article Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50–100 μm) showed minor (~8–9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend. MDPI 2016-11-18 /pmc/articles/PMC5197988/ /pubmed/27869709 http://dx.doi.org/10.3390/jfb7040029 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abutarboush, Rania
Saha, Biswajit K.
Mullah, Saad H.
Arnaud, Francoise G.
Haque, Ashraful
Aligbe, Chioma
Pappas, Georgina
Auker, Charles R.
McCarron, Richard M.
Moon-Massat, Paula F.
Scultetus, Anke H.
Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
title Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
title_full Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
title_fullStr Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
title_full_unstemmed Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
title_short Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
title_sort cerebral microvascular and systemic effects following intravenous administration of the perfluorocarbon emulsion perftoran
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197988/
https://www.ncbi.nlm.nih.gov/pubmed/27869709
http://dx.doi.org/10.3390/jfb7040029
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