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Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population

OBJECTIVE: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chi...

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Autores principales: Sun, Ying, Yuan, Yi, Yang, Hua, Li, Jingjie, Feng, Tian, Ouyang, Yongri, Jin, Tianbo, Liu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197998/
https://www.ncbi.nlm.nih.gov/pubmed/27217259
http://dx.doi.org/10.4274/jcrpe.2784
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author Sun, Ying
Yuan, Yi
Yang, Hua
Li, Jingjie
Feng, Tian
Ouyang, Yongri
Jin, Tianbo
Liu, Ming
author_facet Sun, Ying
Yuan, Yi
Yang, Hua
Li, Jingjie
Feng, Tian
Ouyang, Yongri
Jin, Tianbo
Liu, Ming
author_sort Sun, Ying
collection PubMed
description OBJECTIVE: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chinese women population. METHODS: In this case-control study, 285 Chinese Han women aged 28.50±6.858 years with PCOS and 299 controls of a mean age of 32.66±7.018 years were compared. We selected recently published genome-wide association studies (GWAS) which identified several genetic loci in PCOS. All the SNPs were genotyped by Sequenom Mass-ARRAY technology. Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink. RESULTS: We found that rs705702 in the RAB5B/SUOX was associated with PCOS (odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011) and increased the PCOS risk. The genotypic model analysis also showed that rs705702 was associated with PCOS risk. CONCLUSION: Our results suggest that SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women.
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spelling pubmed-51979982017-01-05 Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population Sun, Ying Yuan, Yi Yang, Hua Li, Jingjie Feng, Tian Ouyang, Yongri Jin, Tianbo Liu, Ming J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chinese women population. METHODS: In this case-control study, 285 Chinese Han women aged 28.50±6.858 years with PCOS and 299 controls of a mean age of 32.66±7.018 years were compared. We selected recently published genome-wide association studies (GWAS) which identified several genetic loci in PCOS. All the SNPs were genotyped by Sequenom Mass-ARRAY technology. Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink. RESULTS: We found that rs705702 in the RAB5B/SUOX was associated with PCOS (odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011) and increased the PCOS risk. The genotypic model analysis also showed that rs705702 was associated with PCOS risk. CONCLUSION: Our results suggest that SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women. Galenos Publishing 2016-12 2016-12-01 /pmc/articles/PMC5197998/ /pubmed/27217259 http://dx.doi.org/10.4274/jcrpe.2784 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sun, Ying
Yuan, Yi
Yang, Hua
Li, Jingjie
Feng, Tian
Ouyang, Yongri
Jin, Tianbo
Liu, Ming
Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
title Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
title_full Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
title_fullStr Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
title_full_unstemmed Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
title_short Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population
title_sort association between common genetic variants and polycystic ovary syndrome risk in a chinese han population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197998/
https://www.ncbi.nlm.nih.gov/pubmed/27217259
http://dx.doi.org/10.4274/jcrpe.2784
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