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Is there a role for diet monotherapy in adult epilepsy?
Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198064/ https://www.ncbi.nlm.nih.gov/pubmed/28053859 http://dx.doi.org/10.1016/j.ebcr.2016.09.005 |
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author | Cervenka, Mackenzie C. Henry-Barron, Bobbie J. Kossoff, Eric H. |
author_facet | Cervenka, Mackenzie C. Henry-Barron, Bobbie J. Kossoff, Eric H. |
author_sort | Cervenka, Mackenzie C. |
collection | PubMed |
description | Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia. Diet monotherapy may be feasible, well-tolerated, and effective for adults with epilepsy who refuse pharmacotherapy and those for whom lifelong diet therapy is recommended. |
format | Online Article Text |
id | pubmed-5198064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-51980642017-01-04 Is there a role for diet monotherapy in adult epilepsy? Cervenka, Mackenzie C. Henry-Barron, Bobbie J. Kossoff, Eric H. Epilepsy Behav Case Rep Case Report Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia. Diet monotherapy may be feasible, well-tolerated, and effective for adults with epilepsy who refuse pharmacotherapy and those for whom lifelong diet therapy is recommended. Elsevier 2016-09-20 /pmc/articles/PMC5198064/ /pubmed/28053859 http://dx.doi.org/10.1016/j.ebcr.2016.09.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Cervenka, Mackenzie C. Henry-Barron, Bobbie J. Kossoff, Eric H. Is there a role for diet monotherapy in adult epilepsy? |
title | Is there a role for diet monotherapy in adult epilepsy? |
title_full | Is there a role for diet monotherapy in adult epilepsy? |
title_fullStr | Is there a role for diet monotherapy in adult epilepsy? |
title_full_unstemmed | Is there a role for diet monotherapy in adult epilepsy? |
title_short | Is there a role for diet monotherapy in adult epilepsy? |
title_sort | is there a role for diet monotherapy in adult epilepsy? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198064/ https://www.ncbi.nlm.nih.gov/pubmed/28053859 http://dx.doi.org/10.1016/j.ebcr.2016.09.005 |
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