A Novel Assay for the Identification of NOTCH1 PEST Domain Mutations in Chronic Lymphocytic Leukemia

Aims. To develop a fast and robust DNA-based assay to detect insertions and deletions mutations in exon 34 that encodes the PEST domain of NOTCH1 in order to evaluate patients with chronic lymphocytic leukemia (CLL). Methods. We designed a multiplexed allele-specific polymerase chain reaction (PCR)...

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Detalles Bibliográficos
Autores principales: Campregher, Paulo Vidal, Petroni, Roberta Cardoso, Muto, Nair Hideko, Sitnik, Roberta, de Carvalho, Flavia Pereira, Bacal, Nydia Strachman, Velloso, Elvira Deolinda Rodrigues Pereira, Oliveira, Gislaine Borba, Pinho, João Renato Rebello, Torres, Davi Coe, Mansur, Marcela Braga, Hassan, Rocio, Lorand-Metze, Irene Gyongyvér Heidemarie, Chiattone, Carlos Sérgio, Hamerschlak, Nelson, Mangueira, Cristovão Luis Pitangueira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198094/
https://www.ncbi.nlm.nih.gov/pubmed/28074183
http://dx.doi.org/10.1155/2016/4247908

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