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Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis

Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell dea...

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Detalles Bibliográficos
Autores principales:	Gong, Yongxing, Schumacher, Steven E., Wu, Wei H., Tang, Fanying, Beroukhim, Rameen, Chan, Timothy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2016
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198112/ https://www.ncbi.nlm.nih.gov/pubmed/28038320 http://dx.doi.org/10.1016/j.neo.2016.12.006

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