Cargando…
Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics
The duration of action of adenosine A(2A) receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro temporal response profiles of a panel of A2A agonists were studied using cAMP assays in recombinantly (CHO) and endoge...
Autores principales: | Hothersall, J. Daniel, Guo, Dong, Sarda, Sunil, Sheppard, Robert J., Chen, Hongming, Keur, Wesley, Waring, Michael J., IJzerman, Adriaan P., Hill, Stephen J., Dale, Ian L., Rawlins, Philip B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198511/ https://www.ncbi.nlm.nih.gov/pubmed/27803241 http://dx.doi.org/10.1124/mol.116.105551 |
Ejemplares similares
-
A two‐state model for the kinetics of competitive radioligand binding
por: Guo, Dong, et al.
Publicado: (2018) -
A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A(3) receptor
por: Bouzo-Lorenzo, Monica, et al.
Publicado: (2019) -
Flexible modulation of agonist efficacy at the human A(3 )adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000
por: Gao, Zhan-Guo, et al.
Publicado: (2008) -
Internalization and desensitization of adenosine receptors
por: Klaasse, Elisabeth C., et al.
Publicado: (2007) -
Molecular probes for the human adenosine receptors
por: Yang, Xue, et al.
Publicado: (2020)