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Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum
INTRODUCTION: Changes in intrinsic functional connectivity (iFC) have been reported at various stages of the Alzheimer's disease (AD) spectrum. We aimed to investigate such alterations over a variety of large-scale intrinsic brain networks (iBNs) across the spectrum of amyloid β positivity and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198881/ https://www.ncbi.nlm.nih.gov/pubmed/28054026 http://dx.doi.org/10.1016/j.dadm.2016.11.006 |
Sumario: | INTRODUCTION: Changes in intrinsic functional connectivity (iFC) have been reported at various stages of the Alzheimer's disease (AD) spectrum. We aimed to investigate such alterations over a variety of large-scale intrinsic brain networks (iBNs) across the spectrum of amyloid β positivity and uncover their relation to cognitive impairment. METHODS: Eight iBNs were defined from resting-state functional magnetic resonance imaging data. In amyloid β–positive healthy subjects, prodromal, and AD patients (N = 70), within-network iFC (intra-iFC) and between-network iFC (inter-iFC) were correlated with scores of cognitive impairment. RESULTS: Across all iBNs, a general degradation in intra-iFC along the scale of cognitive impairment severity was found. Only subtle changes in inter-iFC were identified. DISCUSSION: Across the AD spectrum, changes in iFC that are strongly related to cognitive impairment occur within an extensive variety of networks. |
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