Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells

Gastric cancer (GC) is characterized by amplifications of receptor tyrosine kinases (RTK) and KRAS, therefore, targeting of the RTK/KRAS downstream pathways could help to broaden the applicability of molecular targeted therapy for GC. We assembled a panel of 48 GC cell lines and screened predictors...

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Detalles Bibliográficos
Autores principales: Hirashita, Yuka, Tsukamoto, Yoshiyuki, Yanagihara, Kazuyoshi, Fumoto, Shoichi, Hijiya, Naoki, Nakada, Chisato, Uchida, Tomohisa, Matsuura, Keiko, Kodama, Masaaki, Okimoto, Tadayoshi, Daa, Tsutomu, Seike, Masataka, Iha, Hidekatsu, Shirao, Kuniaki, Murakami, Kazunari, Moriyama, Masatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198963/
https://www.ncbi.nlm.nih.gov/pubmed/27699948
http://dx.doi.org/10.1111/cas.13094

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