A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies

Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds are particularly affected by such neuropathies. Clinical signs appear in young puppies and consist of acral analgesia,...

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Detalles Bibliográficos
Autores principales: Plassais, Jocelyn, Lagoutte, Laetitia, Correard, Solenne, Paradis, Manon, Guaguère, Eric, Hédan, Benoit, Pommier, Alix, Botherel, Nadine, Cadiergues, Marie-Christine, Pilorge, Philippe, Silversides, David, Bizot, Maud, Samuels, Mark, Arnan, Carme, Johnson, Rory, Hitte, Christophe, Salbert, Gilles, Méreau, Agnès, Quignon, Pascale, Derrien, Thomas, André, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198995/
https://www.ncbi.nlm.nih.gov/pubmed/28033318
http://dx.doi.org/10.1371/journal.pgen.1006482

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