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Proteomics reveals the effects of sustained weight loss on the human plasma proteome
Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill‐defined. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12% body weight loss followe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199119/ https://www.ncbi.nlm.nih.gov/pubmed/28007936 http://dx.doi.org/10.15252/msb.20167357 |
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author | Geyer, Philipp E Wewer Albrechtsen, Nicolai J Tyanova, Stefka Grassl, Niklas Iepsen, Eva W Lundgren, Julie Madsbad, Sten Holst, Jens J Torekov, Signe S Mann, Matthias |
author_facet | Geyer, Philipp E Wewer Albrechtsen, Nicolai J Tyanova, Stefka Grassl, Niklas Iepsen, Eva W Lundgren, Julie Madsbad, Sten Holst, Jens J Torekov, Signe S Mann, Matthias |
author_sort | Geyer, Philipp E |
collection | PubMed |
description | Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill‐defined. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12% body weight loss followed by a year of weight maintenance. Using mass spectrometry‐based plasma proteome profiling, we measured 1,294 plasma proteomes. Longitudinal monitoring of the cohort revealed individual‐specific protein levels with wide‐ranging effects of losing weight on the plasma proteome reflected in 93 significantly affected proteins. The adipocyte‐secreted SERPINF1 and apolipoprotein APOF1 were most significantly regulated with fold changes of −16% and +37%, respectively (P < 10(−13)), and the entire apolipoprotein family showed characteristic differential regulation. Clinical laboratory parameters are reflected in the plasma proteome, and eight plasma proteins correlated better with insulin resistance than the known marker adiponectin. Nearly all study participants benefited from weight loss regarding a ten‐protein inflammation panel defined from the proteomics data. We conclude that plasma proteome profiling broadly evaluates and monitors intervention in metabolic diseases. |
format | Online Article Text |
id | pubmed-5199119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51991192016-12-30 Proteomics reveals the effects of sustained weight loss on the human plasma proteome Geyer, Philipp E Wewer Albrechtsen, Nicolai J Tyanova, Stefka Grassl, Niklas Iepsen, Eva W Lundgren, Julie Madsbad, Sten Holst, Jens J Torekov, Signe S Mann, Matthias Mol Syst Biol Articles Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill‐defined. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12% body weight loss followed by a year of weight maintenance. Using mass spectrometry‐based plasma proteome profiling, we measured 1,294 plasma proteomes. Longitudinal monitoring of the cohort revealed individual‐specific protein levels with wide‐ranging effects of losing weight on the plasma proteome reflected in 93 significantly affected proteins. The adipocyte‐secreted SERPINF1 and apolipoprotein APOF1 were most significantly regulated with fold changes of −16% and +37%, respectively (P < 10(−13)), and the entire apolipoprotein family showed characteristic differential regulation. Clinical laboratory parameters are reflected in the plasma proteome, and eight plasma proteins correlated better with insulin resistance than the known marker adiponectin. Nearly all study participants benefited from weight loss regarding a ten‐protein inflammation panel defined from the proteomics data. We conclude that plasma proteome profiling broadly evaluates and monitors intervention in metabolic diseases. John Wiley and Sons Inc. 2016-12-22 /pmc/articles/PMC5199119/ /pubmed/28007936 http://dx.doi.org/10.15252/msb.20167357 Text en © 2016 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Geyer, Philipp E Wewer Albrechtsen, Nicolai J Tyanova, Stefka Grassl, Niklas Iepsen, Eva W Lundgren, Julie Madsbad, Sten Holst, Jens J Torekov, Signe S Mann, Matthias Proteomics reveals the effects of sustained weight loss on the human plasma proteome |
title | Proteomics reveals the effects of sustained weight loss on the human plasma proteome |
title_full | Proteomics reveals the effects of sustained weight loss on the human plasma proteome |
title_fullStr | Proteomics reveals the effects of sustained weight loss on the human plasma proteome |
title_full_unstemmed | Proteomics reveals the effects of sustained weight loss on the human plasma proteome |
title_short | Proteomics reveals the effects of sustained weight loss on the human plasma proteome |
title_sort | proteomics reveals the effects of sustained weight loss on the human plasma proteome |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199119/ https://www.ncbi.nlm.nih.gov/pubmed/28007936 http://dx.doi.org/10.15252/msb.20167357 |
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