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Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-mingle with T cells. Here we show that splenic or, un...

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Detalles Bibliográficos
Autores principales:	Ku, Amy W, Muhitch, Jason B, Powers, Colin A, Diehl, Michael, Kim, Minhyung, Fisher, Daniel T, Sharda, Anand P, Clements, Virginia K, O'Loughlin, Kieran, Minderman, Hans, Messmer, Michelle N, Ma, Jing, Skitzki, Joseph J, Steeber, Douglas A, Walcheck, Bruce, Ostrand-Rosenberg, Suzanne, Abrams, Scott I, Evans, Sharon S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199197/ https://www.ncbi.nlm.nih.gov/pubmed/27929373 http://dx.doi.org/10.7554/eLife.17375

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