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Adjuvant-Induced Arthritis in Guinea Pigs

We propose a model of rheumatoid arthritis (RA) induced in outbred guinea pigs using a single subcutaneous injection of complete Freund’s adjuvant to the hind paw. Histological examination of this model shows fibrin deposition on the surface of the synovial membrane, leukocyte infiltration of the sy...

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Autores principales: Taranov, O.S., Yakubitskiy, S.N., Nepomnyashchikh, T.S., Nesterov, A.E., Shchelkunov, S.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199212/
https://www.ncbi.nlm.nih.gov/pubmed/28050272
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author Taranov, O.S.
Yakubitskiy, S.N.
Nepomnyashchikh, T.S.
Nesterov, A.E.
Shchelkunov, S.N.
author_facet Taranov, O.S.
Yakubitskiy, S.N.
Nepomnyashchikh, T.S.
Nesterov, A.E.
Shchelkunov, S.N.
author_sort Taranov, O.S.
collection PubMed
description We propose a model of rheumatoid arthritis (RA) induced in outbred guinea pigs using a single subcutaneous injection of complete Freund’s adjuvant to the hind paw. Histological examination of this model shows fibrin deposition on the surface of the synovial membrane, leukocyte infiltration of the synovial membrane and adjacent tissues, proliferation of the granulation tissue, and emergence of angioid areas, characteristic of RA. The cell response appears as an increase in the plasma cell count and development of follicle-like lymphoid infiltrates; erosion of the articular surface of the cartilage, frequently with deep cartilage destruction over large areas; and epiphysiopathy. The high reproducibility of arthritis induction in this RA model has been demonstrated. The proposed model is promising for the assessment of anti-arthritis preparations and dosage regimens.
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spelling pubmed-51992122017-01-03 Adjuvant-Induced Arthritis in Guinea Pigs Taranov, O.S. Yakubitskiy, S.N. Nepomnyashchikh, T.S. Nesterov, A.E. Shchelkunov, S.N. Acta Naturae Research Article We propose a model of rheumatoid arthritis (RA) induced in outbred guinea pigs using a single subcutaneous injection of complete Freund’s adjuvant to the hind paw. Histological examination of this model shows fibrin deposition on the surface of the synovial membrane, leukocyte infiltration of the synovial membrane and adjacent tissues, proliferation of the granulation tissue, and emergence of angioid areas, characteristic of RA. The cell response appears as an increase in the plasma cell count and development of follicle-like lymphoid infiltrates; erosion of the articular surface of the cartilage, frequently with deep cartilage destruction over large areas; and epiphysiopathy. The high reproducibility of arthritis induction in this RA model has been demonstrated. The proposed model is promising for the assessment of anti-arthritis preparations and dosage regimens. A.I. Gordeyev 2016 /pmc/articles/PMC5199212/ /pubmed/28050272 Text en Copyright ® 2016 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Taranov, O.S.
Yakubitskiy, S.N.
Nepomnyashchikh, T.S.
Nesterov, A.E.
Shchelkunov, S.N.
Adjuvant-Induced Arthritis in Guinea Pigs
title Adjuvant-Induced Arthritis in Guinea Pigs
title_full Adjuvant-Induced Arthritis in Guinea Pigs
title_fullStr Adjuvant-Induced Arthritis in Guinea Pigs
title_full_unstemmed Adjuvant-Induced Arthritis in Guinea Pigs
title_short Adjuvant-Induced Arthritis in Guinea Pigs
title_sort adjuvant-induced arthritis in guinea pigs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199212/
https://www.ncbi.nlm.nih.gov/pubmed/28050272
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