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RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable intracellular sequences flanking the tyrosine kinase domain and specific patterns of...

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Detalles Bibliográficos
Autores principales:	Plaza-Menacho, Iván, Barnouin, Karin, Barry, Rachael, Borg, Annabel, Orme, Mariam, Chauhan, Rakhee, Mouilleron, Stephane, Martínez-Torres, Rubén J., Meier, Pascal, McDonald, Neil Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199340/ https://www.ncbi.nlm.nih.gov/pubmed/28009299 http://dx.doi.org/10.1016/j.celrep.2016.11.061

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