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novoBreak: local assembly for breakpoint detection in cancer genomes

We present novoBreak, a novel genome-wide local assembly algorithm that discovers somatic and germline structural variation breakpoints in whole genome sequencing data. In the ICGC-TCGA DREAM 8.5 Somatic Mutation Calling Challenge and real cancer genome data analysis, novoBreak consistently outperfo...

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Detalles Bibliográficos
Autores principales:	Chong, Zechen, Ruan, Jue, Gao, Min, Zhou, Wanding, Chen, Tenghui, Fan, Xian, Ding, Li, Lee, Anna Y., Boutros, Paul, Chen, Junjie, Chen, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199621/ https://www.ncbi.nlm.nih.gov/pubmed/27892959 http://dx.doi.org/10.1038/nmeth.4084

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