Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy

This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study pa...

Descripción completa

Detalles Bibliográficos
Autores principales: González-Cuevas, Montserrat, Romero, Odile, Toledo, Manuel, Quintana, Manuel, Cambrodí, Roser, Santamarina, Estevo, Jurado, Maria José, Ferrer, Alex, Salas-Puig, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200874/
https://www.ncbi.nlm.nih.gov/pubmed/28066710
http://dx.doi.org/10.1016/j.ebcr.2016.10.002
Descripción
Sumario:This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy.

Ejemplares similares