Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy

This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study pa...

Descripción completa

Detalles Bibliográficos
Autores principales: González-Cuevas, Montserrat, Romero, Odile, Toledo, Manuel, Quintana, Manuel, Cambrodí, Roser, Santamarina, Estevo, Jurado, Maria José, Ferrer, Alex, Salas-Puig, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200874/
https://www.ncbi.nlm.nih.gov/pubmed/28066710
http://dx.doi.org/10.1016/j.ebcr.2016.10.002
_version_ 1782489257197174784
author González-Cuevas, Montserrat
Romero, Odile
Toledo, Manuel
Quintana, Manuel
Cambrodí, Roser
Santamarina, Estevo
Jurado, Maria José
Ferrer, Alex
Salas-Puig, Xavier
author_facet González-Cuevas, Montserrat
Romero, Odile
Toledo, Manuel
Quintana, Manuel
Cambrodí, Roser
Santamarina, Estevo
Jurado, Maria José
Ferrer, Alex
Salas-Puig, Xavier
author_sort González-Cuevas, Montserrat
collection PubMed
description This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy.
format Online
Article
Text
id pubmed-5200874
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-52008742017-01-06 Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy González-Cuevas, Montserrat Romero, Odile Toledo, Manuel Quintana, Manuel Cambrodí, Roser Santamarina, Estevo Jurado, Maria José Ferrer, Alex Salas-Puig, Xavier Epilepsy Behav Case Rep Case Report This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy. Elsevier 2016-10-21 /pmc/articles/PMC5200874/ /pubmed/28066710 http://dx.doi.org/10.1016/j.ebcr.2016.10.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
González-Cuevas, Montserrat
Romero, Odile
Toledo, Manuel
Quintana, Manuel
Cambrodí, Roser
Santamarina, Estevo
Jurado, Maria José
Ferrer, Alex
Salas-Puig, Xavier
Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
title Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
title_full Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
title_fullStr Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
title_full_unstemmed Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
title_short Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
title_sort effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200874/
https://www.ncbi.nlm.nih.gov/pubmed/28066710
http://dx.doi.org/10.1016/j.ebcr.2016.10.002
work_keys_str_mv AT gonzalezcuevasmontserrat effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT romeroodile effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT toledomanuel effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT quintanamanuel effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT cambrodiroser effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT santamarinaestevo effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT juradomariajose effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT ferreralex effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy
AT salaspuigxavier effectofadjunctiveperampanelonthequalityofsleepanddaytimesomnolenceinpatientswithepilepsy

Ejemplares similares