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Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras

[Image: see text] Selective degradation of proteins by proteolysis targeting chimeras (PROTACs) offers a promising potential alternative to protein inhibition for therapeutic intervention. Current PROTAC molecules incorporate a ligand for the target protein, a linker, and an E3 ubiquitin ligase recr...

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Detalles Bibliográficos
Autores principales:	Lebraud, Honorine, Wright, David J., Johnson, Christopher N., Heightman, Tom D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200928/ https://www.ncbi.nlm.nih.gov/pubmed/28058282 http://dx.doi.org/10.1021/acscentsci.6b00280

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