Metastatic meningioma presenting as a malignant soft tissue tumour

BACKGROUND: Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised. CASE PRESENTATION: We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscl...

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Autores principales: McCarthy, Catherine, Hofer, Monika, Vlychou, Marianna, Khundkar, Robar, Critchley, Paul, Cudlip, Simon, Ansorge, Olaf, Athanasou, Nick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200959/
https://www.ncbi.nlm.nih.gov/pubmed/28042470
http://dx.doi.org/10.1186/s13569-016-0063-1
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author McCarthy, Catherine
Hofer, Monika
Vlychou, Marianna
Khundkar, Robar
Critchley, Paul
Cudlip, Simon
Ansorge, Olaf
Athanasou, Nick A.
author_facet McCarthy, Catherine
Hofer, Monika
Vlychou, Marianna
Khundkar, Robar
Critchley, Paul
Cudlip, Simon
Ansorge, Olaf
Athanasou, Nick A.
author_sort McCarthy, Catherine
collection PubMed
description BACKGROUND: Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised. CASE PRESENTATION: We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscle. The patient had previously undergone surgery for a right frontal lobe high grade anaplastic meningioma. Histology of the soft tissue lesion showed metastatic anaplastic meningioma with clumps of pleomorphic tumour cells which expressed epithelial membrane antigen, cytokeratin and P63 but were negative for other epithelial and mesenchymal markers. A PET-CT scan revealed additional metastatic lesions in the left pleura, liver and iliac bone. CONCLUSIONS: Metastatic malignant meningioma can very rarely present as a high grade pleomorphic malignant soft tissue tumour and needs to be distinguished from soft tissue sarcomas and metastatic carcinomas that express epithelial antigens.
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spelling pubmed-52009592016-12-30 Metastatic meningioma presenting as a malignant soft tissue tumour McCarthy, Catherine Hofer, Monika Vlychou, Marianna Khundkar, Robar Critchley, Paul Cudlip, Simon Ansorge, Olaf Athanasou, Nick A. Clin Sarcoma Res Case Report BACKGROUND: Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised. CASE PRESENTATION: We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscle. The patient had previously undergone surgery for a right frontal lobe high grade anaplastic meningioma. Histology of the soft tissue lesion showed metastatic anaplastic meningioma with clumps of pleomorphic tumour cells which expressed epithelial membrane antigen, cytokeratin and P63 but were negative for other epithelial and mesenchymal markers. A PET-CT scan revealed additional metastatic lesions in the left pleura, liver and iliac bone. CONCLUSIONS: Metastatic malignant meningioma can very rarely present as a high grade pleomorphic malignant soft tissue tumour and needs to be distinguished from soft tissue sarcomas and metastatic carcinomas that express epithelial antigens. BioMed Central 2016-12-30 /pmc/articles/PMC5200959/ /pubmed/28042470 http://dx.doi.org/10.1186/s13569-016-0063-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
McCarthy, Catherine
Hofer, Monika
Vlychou, Marianna
Khundkar, Robar
Critchley, Paul
Cudlip, Simon
Ansorge, Olaf
Athanasou, Nick A.
Metastatic meningioma presenting as a malignant soft tissue tumour
title Metastatic meningioma presenting as a malignant soft tissue tumour
title_full Metastatic meningioma presenting as a malignant soft tissue tumour
title_fullStr Metastatic meningioma presenting as a malignant soft tissue tumour
title_full_unstemmed Metastatic meningioma presenting as a malignant soft tissue tumour
title_short Metastatic meningioma presenting as a malignant soft tissue tumour
title_sort metastatic meningioma presenting as a malignant soft tissue tumour
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200959/
https://www.ncbi.nlm.nih.gov/pubmed/28042470
http://dx.doi.org/10.1186/s13569-016-0063-1
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