Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16(INK4a) or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

OBJECTIVES: As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest. p16(INK4a) expression, a marker for aging and senescence in T-cells, is associated with lower intracellular concentrations of end...

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Detalles Bibliográficos
Autores principales: Maas, Brian M., Francis, Owen, Mollan, Katie R., Lee, Cynthia, Cottrell, Mackenzie L., Prince, Heather M. A., Sykes, Craig, Trezza, Christine, Torrice, Chad, White, Nicole, Malone, Stephanie, Hudgens, Michael G., Sharpless, Norman E., Dumond, Julie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201235/
https://www.ncbi.nlm.nih.gov/pubmed/28036343
http://dx.doi.org/10.1371/journal.pone.0168709

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