A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization

In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated form of semaphorin-3C that is resistant to cleavage by furin like pro-protein convertases (FPPC). We have found in previous work that FR-sema...

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Detalles Bibliográficos
Autores principales: Toledano, Shira, Lu, Huayi, Palacio, Agustina, Ziv, Keren, Kessler, Ofra, Schaal, Shlomit, Neufeld, Gera, Barak, Yoreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201251/
https://www.ncbi.nlm.nih.gov/pubmed/28036336
http://dx.doi.org/10.1371/journal.pone.0168122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201251/
https://www.ncbi.nlm.nih.gov/pubmed/28036336
http://dx.doi.org/10.1371/journal.pone.0168122

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