Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

Catalytically inactive enzyme paralogs occur in many genomes. Some regulate their active counterparts but the structural principles of this regulation remain largely unknown. We report X-ray structures of Trypanosoma brucei S-adenosylmethionine decarboxylase alone and in functional complex with its...

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Detalles Bibliográficos
Autores principales: Volkov, Oleg A, Kinch, Lisa, Ariagno, Carson, Deng, Xiaoyi, Zhong, Shihua, Grishin, Nick, Tomchick, Diana R, Chen, Zhe, Phillips, Margaret A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201418/
https://www.ncbi.nlm.nih.gov/pubmed/27977001
http://dx.doi.org/10.7554/eLife.20198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201418/
https://www.ncbi.nlm.nih.gov/pubmed/27977001
http://dx.doi.org/10.7554/eLife.20198

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