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Antioxidant supplements and semen parameters: An evidence based review

Many studies have focused on male infertility. There is limited evidence about the influence of nutrition on quality of semen. Approximately, 30-80% of infertility cases are caused by oxidative stress and decreased level of seminal total antioxidant capacity. This study was aimed to review the effec...

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Autores principales: Ahmadi, Sedigheh, Bashiri, Reihane, Ghadiri-Anari, Akram, Nadjarzadeh, Azadeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203687/
https://www.ncbi.nlm.nih.gov/pubmed/28066832
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author Ahmadi, Sedigheh
Bashiri, Reihane
Ghadiri-Anari, Akram
Nadjarzadeh, Azadeh
author_facet Ahmadi, Sedigheh
Bashiri, Reihane
Ghadiri-Anari, Akram
Nadjarzadeh, Azadeh
author_sort Ahmadi, Sedigheh
collection PubMed
description Many studies have focused on male infertility. There is limited evidence about the influence of nutrition on quality of semen. Approximately, 30-80% of infertility cases are caused by oxidative stress and decreased level of seminal total antioxidant capacity. This study was aimed to review the effects of oral antioxidant supplements on improving major semen parameters such as sperm concentration, motility, morphology, DNA damage, and fertility rate. Data were extracted from PubMed and Google scholar database by using the terms “antioxidant”, “multivitamin”, “carnitine”, “CoQ10”, “vitamin C”, “vitamin E”, “zinc”, “folic acid”, “N-acetyl cysteine” and “selenium” combined with “male infertility”, “semen”, and “sperm” to generate a set of relevant citations. Supplements such as CoQ10 and alpha-tocopherol significantly improve sperm count. Also, carnitine has positive effects on sperm motility and morphology. Simultaneous administration of vitamin E and vitamin C reduces the sperm DNA damage. However, in some studies, one or more factors have not changed substantially. In most of the studies, antioxidant supplementation improved the number, motility, morphology and sometimes DNA integrity of sperm. The present study showed that antioxidant supplements, especially a combination of antioxidants such as vitamin C, vitamin E, and CoQ10 intake can effectively improve semen parameters in infertile men.
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spelling pubmed-52036872017-01-06 Antioxidant supplements and semen parameters: An evidence based review Ahmadi, Sedigheh Bashiri, Reihane Ghadiri-Anari, Akram Nadjarzadeh, Azadeh Int J Reprod Biomed Evidence Based Review Many studies have focused on male infertility. There is limited evidence about the influence of nutrition on quality of semen. Approximately, 30-80% of infertility cases are caused by oxidative stress and decreased level of seminal total antioxidant capacity. This study was aimed to review the effects of oral antioxidant supplements on improving major semen parameters such as sperm concentration, motility, morphology, DNA damage, and fertility rate. Data were extracted from PubMed and Google scholar database by using the terms “antioxidant”, “multivitamin”, “carnitine”, “CoQ10”, “vitamin C”, “vitamin E”, “zinc”, “folic acid”, “N-acetyl cysteine” and “selenium” combined with “male infertility”, “semen”, and “sperm” to generate a set of relevant citations. Supplements such as CoQ10 and alpha-tocopherol significantly improve sperm count. Also, carnitine has positive effects on sperm motility and morphology. Simultaneous administration of vitamin E and vitamin C reduces the sperm DNA damage. However, in some studies, one or more factors have not changed substantially. In most of the studies, antioxidant supplementation improved the number, motility, morphology and sometimes DNA integrity of sperm. The present study showed that antioxidant supplements, especially a combination of antioxidants such as vitamin C, vitamin E, and CoQ10 intake can effectively improve semen parameters in infertile men. Research and Clinical Center for Infertility 2016-12 /pmc/articles/PMC5203687/ /pubmed/28066832 Text en http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Evidence Based Review
Ahmadi, Sedigheh
Bashiri, Reihane
Ghadiri-Anari, Akram
Nadjarzadeh, Azadeh
Antioxidant supplements and semen parameters: An evidence based review
title Antioxidant supplements and semen parameters: An evidence based review
title_full Antioxidant supplements and semen parameters: An evidence based review
title_fullStr Antioxidant supplements and semen parameters: An evidence based review
title_full_unstemmed Antioxidant supplements and semen parameters: An evidence based review
title_short Antioxidant supplements and semen parameters: An evidence based review
title_sort antioxidant supplements and semen parameters: an evidence based review
topic Evidence Based Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203687/
https://www.ncbi.nlm.nih.gov/pubmed/28066832
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